DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PpN58A and Ppp3cc

DIOPT Version :9

Sequence 1:	NP_477384.1	Gene:	PpN58A / 37493	FlyBaseID:	FBgn0025573	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001291920.1	Gene:	Ppp3cc / 19057	MGIID:	107162	Length:	522	Species:	Mus musculus

Alignment Length:	314	Identity:	110/314 - (35%)
Similarity:	170/314 - (54%)	Gaps:	42/314 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MKKLLSNGSNKNKTLK---FDEGINLDQIIAKLKLIGEIGSVVQISVREIEAVCSRAREVLLKQP 63
            :|::..||..|...||   ..|| .:::.:| ||:|.:                  ...:|.::.
Mouse    28 LKEVFENGKPKMDLLKNHLVKEG-RVEEEVA-LKIIND------------------GAAILKQEK 72

  Fly    64 TLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYP 128
            |::|:.|||.:.||:|||:.:|::.||..|.|.::.||.||||||||..|||.:..|.:||..:|
Mouse    73 TMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHP 137

  Fly   129 TKFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHL 193
            ...:||||||||..:..::.|..||:.:|:..::...:..::||||||::.:...|.|||:||.:
Mouse   138 KTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPEI 202

  Fly   194 FSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNE----------RGVSHTFGSDVVSAF 248
            ..::.||::.|..|.|..|.:||:|||||   :..:|..:          ||.|:.|....|..|
Mouse   203 TCLEDIRKLDRFSEPPAFGPVCDLLWSDP---LEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEF 264

  Fly   249 LHRFKLNLICRGHQVVEDGYEFFAKRQ------LITIFSAPNYCGEFDNAGAMM 296
            |....|..|.|.|:..:.||..:.|.|      ||||||||||...::|..|::
Mouse   265 LQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpN58A	NP_477384.1	PTZ00480	22..311	CDD:185658	102/291 (35%)
PpN58A	NP_477384.1	MPP_superfamily	23..311	CDD:301300	102/290 (35%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	107/305 (35%)
		Catalytic. /evidence=ECO:0000305	52..343		102/289 (35%)
		PP2Ac	54..325	CDD:197547	102/287 (36%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	394..408
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	409..416
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	467..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910