DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comr and MUC4

DIOPT Version :9

Sequence 1:	NP_611617.1	Gene:	comr / 37492	FlyBaseID:	FBgn0034667	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001309397.1	Gene:	MUC4 / 4585	HGNCID:	7514	Length:	7418	Species:	Homo sapiens

Alignment Length:	623	Identity:	115/623 - (18%)
Similarity:	191/623 - (30%)	Gaps:	221/623 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGNQDTLGQSQQVNESGDEYEEDAATSWTNELEQQESRTPADSPEFLDFVDSEDPLEDFERNPLQ 66
            |||...:|.|     |||.|                                      ||.:||.
Human  6506 SGNPVLMGFS-----SGDGY--------------------------------------FENSPLM 6527

  Fly    67 KEPLDLAVKPVSDINKKAAENHRRIYRQLGIHIPETP----------KSHPLLHYAFVVKLFLAT 121
            .:|:....:|...:|..:.....:.||   :|..|.|          ||.|
Human  6528 SQPVWERYRPDRFLNSNSGLQGLQFYR---LHREERPNYRLECLQWLKSQP-------------- 6575

  Fly   122 DNSSIHYLKWSANGRELEVDYQGMQEHLSSGCSMFHCRNTLQFTGTLLAHGFERVSLKDVRKSSA 186
                    :|.:.|          ...:|..||....|..|:|....:.    |..|...:..|.
Human  6576 --------RWPSWG----------WNQVSCPCSWQQGRRDLRFQPVSIG----RWGLGSRQLCSF 6618

  Fly   187 TN----ITLIYRNP--NFVKG-QLLKLHKLAQECEKIPEI------SSP---GTAEPRRPPLHLP 235
            |:    :...| .|  .|.:| .:.:..:||||.|  |:.      ..|   ...:.|||
Human  6619 TSWRGGVCCSY-GPWGEFREGWHVQRPWQLAQELE--PQSWCCRWNDKPYLCALYQQRRP----- 6675

  Fly   236 NYAHISRMVRRGDLCSTPYTSRSALQVARCHFQTLLGYQADLGVLKD------RNNHDMFNKNIM 294
               |:.        |:|....:.|......|..||.|.......|.|      ::.:..|   ::
Human  6676 ---HVG--------CATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSF---LL 6726

  Fly   295 TQLNVKRGRSSINN--------APVDLAPSKVSFEKFVKPHESV----INIGIGQAPDYAGYYGQ 347
            .....:.|.:...|        ....|.|  |:.:..::||:::    .|..:...||:....||
Human  6727 QGRTAQTGSAQATNFIAFAAQYRSSSLGP--VTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQ 6789

  Fly   348 VELFKVNEFFSEYLPRYGSKIT----GYKEIVMDATNKSIGFQQNLP----------IGMNYSDD 398
             |.|...   ...|.|.||:::    |:..:.:.|.:..:....:||          :|:..::.
Human  6790 -ETFNAT---GVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNP 6850

  Fly   399 EDD-------ALPPISSDLDL-------------------DFMPST------SAAAKMKSTGRKV 431
            |||       .:||.|.:..|                   |.:||.      |...|..|....:
Human  6851 EDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQLQKNSSWAEHL 6915

  Fly   432 VEDSDLEQAMQELCGGSN-LNEEEELPQTSTRFKAKPKPRAKTKAKPTKRQAKPVHSSSSECEDF 495
            :.:.|         |.|: :.:...|...|.....:...:...:|..|..|..|         ..
Human  6916 ISNCD---------GDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPP---------SI 6962

  Fly   496 KPDEVYEGFKSRNPKNVKLKPSDENISYTLEEG-TDFE 532
            ....|.|.:|.:... ::...:.|:.::||.:. ||.|
Human  6963 NGGRVIEAYKGQTTL-IQYTSNAEDANFTLRDSCTDLE 6999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comr	NP_611617.1	HSF_DNA-bind	124..208	CDD:299902	16/90 (18%)
MUC4	NP_001309397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..254
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..291
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..969
		NIDO	6403..6560	CDD:214712	19/99 (19%)
		AMOP	6559..6674	CDD:128962	28/153 (18%)
		VWD	6679..6859	CDD:214566	36/188 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N08
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900