DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9294 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_995920.1	Gene:	CG9294 / 37491	FlyBaseID:	FBgn0034666	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	250	Identity:	82/250 - (32%)
Similarity:	128/250 - (51%)	Gaps:	17/250 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 CGLINTLYKIVGGQETRVHQYPWMAVILIYNRFYCSGSLINDLYVLTAAHCVEGVP-PELITLR- 154
            ||......:|||||.....::||.|.:.:..|..|.||::...:|:|||||:.... ..|.:.|
Human   209 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRV 273

  Fly   155 ---FLEHNRSHSNDDIVIQRYVSRVKVHELYNPRSFDNDLAVLRLNQPLDMRHHRLRPICLPVQS 216
               .:.|:....:...:::|.:.    |.||:.::.|.|:|:|||...|:. ...:..:|||.:.
Human   274 HAGLVSHSAVRPHQGALVERIIP----HPLYSAQNHDYDVALLRLQTALNF-SDTVGAVCLPAKE 333

  Fly   217 YSFDHELGI-VAGWG-AQREGGFGTDTLREVDVVVLPQSECRNGTTYRPGQITDNMMCAGYISEG 279
            ..|...... |:||| ......:.:|.|::..|.:.....|.:...| .|.:|..|:||||: :|
Human   334 QHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVY-SGALTPRMLCAGYL-DG 396

  Fly   280 GKDACSGDSGGPLQTTFDEQPGQYQLAGIVSWGVGCARPQSPGVYTRVNQYLRWL 334
            ..|||.|||||||.....:   .::|.|:||||.|||.|..||||.:|.::|.|:
Human   397 RADACQGDSGGPLVCPDGD---TWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9294	NP_995920.1	Tryp_SPc	100..333	CDD:214473	79/239 (33%)
CG9294	NP_995920.1	Tryp_SPc	101..334	CDD:238113	79/239 (33%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	2/3 (67%)
		Tryp_SPc	217..448	CDD:214473	79/240 (33%)
		Tryp_SPc	218..451	CDD:238113	80/240 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960