DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9294 and KLKB1

DIOPT Version :9

Sequence 1:	NP_995920.1	Gene:	CG9294 / 37491	FlyBaseID:	FBgn0034666	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	263	Identity:	97/263 - (36%)
Similarity:	143/263 - (54%)	Gaps:	31/263 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CVTCRCGLINTLYKIVGGQETRVHQYPW---MAVILIYNRFYCSGSLINDLYVLTAAHCVEGVPP 148
            |.|      .|..:||||..:...::||   :.|.|...|..|.||||...:|||||||.:|:|.
Human   394 CTT------KTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPL 452

  Fly   149 ELITLRFLEHNRSHSN----DDIVIQRYVSRVK---VHELYNPRSFDNDLAVLRLNQPLDMRHHR 206
            :.:.       |.:|.    .||......|::|   :|:.|.....::|:|:::|..||:....:
Human   453 QDVW-------RIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQ 510

  Fly   207 LRPICLPVQ-SYSFDHELGIVAGWGAQREGGFGTDTLREVDVVVLPQSECRNGTTYRPGQITDNM 270
             :|||||.: ..|..:....|.|||..:|.|...:.|::|::.::...||:.  .|:..:||..|
Human   511 -KPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQK--RYQDYKITQRM 572

  Fly   271 MCAGYISEGGKDACSGDSGGPLQTTFDEQPGQYQLAGIVSWGVGCARPQSPGVYTRVNQYLRWLG 335
            :|||| .|||||||.|||||||..   :..|.::|.||.|||.||||.:.|||||:|.:|:.|:.
Human   573 VCAGY-KEGGKDACKGDSGGPLVC---KHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWIL 633

  Fly   336 SNT 338
            ..|
Human   634 EKT 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9294	NP_995920.1	Tryp_SPc	100..333	CDD:214473	92/243 (38%)
CG9294	NP_995920.1	Tryp_SPc	101..334	CDD:238113	92/243 (38%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	92/244 (38%)
		Tryp_SPc	402..632	CDD:238113	92/243 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910