DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9294 and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_995920.1	Gene:	CG9294 / 37491	FlyBaseID:	FBgn0034666	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	261	Identity:	87/261 - (33%)
Similarity:	128/261 - (49%)	Gaps:	31/261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 CG--LINTLY---KIVGGQETRVHQYPWMAVILIYNRFYCSGSLINDLYVLTAAHCVEGVPPELI 151
            ||  :.|::.   |||.|:.:....:||.|.:....|.||..|||:..::|:||||
Human   171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHC--------- 226

  Fly   152 TLRFLEHNRSHS---NDDIVIQ-----RYVSRVKVHELYNPRSFDNDLAVLRLNQPLDMRHHRLR 208
               |.:.|.|..   |..||:.     |.|..:..||.|:.....:|:|:::|.:.:....: :|
Human   227 ---FAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEY-IR 287

  Fly   209 PICLPVQSYSF-DHELGIVAGWGAQREGGFGTDTLREVDVVVLPQSECRNGTTYRPGQITDNMMC 272
            .||||...... :::..:|.|||.....|.....|:|..:.::....|.....| .|.:||.|:|
Human   288 KICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAY-SGFVTDTMLC 351

  Fly   273 AGYISEGGKDACSGDSGGPLQTTFDEQPGQYQLAGIVSWGVGCARPQSPGVYTRVNQYLRWLGSN 337
            ||::| |..|||..||||||  .:.:....:.|.||||||.||.:...|||||||..|..|:.|.
Human   352 AGFMS-GEADACQNDSGGPL--AYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSK 413

  Fly   338 T 338
            |
Human   414 T 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9294	NP_995920.1	Tryp_SPc	100..333	CDD:214473	81/241 (34%)
CG9294	NP_995920.1	Tryp_SPc	101..334	CDD:238113	80/241 (33%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699
		Tryp_SPc	184..410	CDD:214473	81/242 (33%)
		Tryp_SPc	185..413	CDD:238113	81/244 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41415
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920