Protein Alignment KCNC4 and Shab

DIOPT Version :9

• Sequence 1: XP_024302558.1
• Gene: KCNC4 / 3749
• HGNCID: 6236
• Length: 661
• Species: Homo sapiens
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 201/635 - (31%)
• Similarity: 296/635 - (46%)
• Gaps: 100/635 - (15%)

Human    19 PPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGS 83
            ||....:.:..|   .:.::.|||||.|||....||..||.|||..|.:      ..|....|..
  Fly   293 PPEPFMIAQSKA---VNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRE------CTTHEAIVEL 348

Human    84 SGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 148
            .........|:||||||..|:.:||:|||||||...::|...|.::|.:||:||..:|.||...|
  Fly   349 CDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKY 413

Human   149 RQHRD------AEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRG 207
            .|.::      .:||..:.:.                ||.|.                |.|.|..
  Fly   414 HQRKENVHEEMRKEAESLRQR----------------DEEEF----------------GEGKCAE 446

Human   208 WQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFR 272
            :|..:|.|.|.|.:|.||||:|..|:.||::|.....|.|         :.::..:.|.|.
  Fly   447 YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNT---------LPQLQHIDNGTP---- 498

Human   273 REVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSK 337
               :..|.|..:|.||:.|||||:::|....||...|.|..|||||.:||||:::.:.|...:..
  Fly   499 ---QDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN 560

Human   338 AA---RDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 399
            |.   :||...::|.|.:|||||.||.||..||:.||.|||.|..|..||::|||:|||||:::.
  Fly   561 ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLA 625

Human   400 YYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTI 464
            |:||         :....|.|.:||..||||.:||||:||||:||.|..|.::|.:|.:.|||.|
  Fly   626 YFAE---------KDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVI 681

Human   465 AMPVPVIVNNFGMYYSLAMAKQKLPKKRK--KHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPA 527
            |:|:|:|||||..:|...|.::|..|:|:  ....|...:.|..:...::...:.....|.....
  Fly   682 ALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDT 746

Human   528 REEGMI---ERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAAC 589
            .::..:   :.||..:...|.....:....|..|:|...:|...|.......:||
  Fly   747 GKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPATT---------- 801

Human   590 FLLSTGDYACADGSVRKGCGKSRSLNNIVGAAGTSLGLSPLASRYSLPYP 639
               .||.|...|.....   ::.:|:|..|::.....:.|    ||...|
  Fly   802 ---GTGCYKNYDHVANL---RNSNLHNRRGSSSEQDAVPP----YSFDNP 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC4	XP_024302558.1	Potassium_chann	1..29	CDD:314363	2/9 (22%)
		BTB_2	38..143	CDD:308049	43/104 (41%)
		Ion_trans	225..483	CDD:306908	108/260 (42%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	46/112 (41%)
		BTB_2	309..408	CDD:280393	43/104 (41%)
		Ion_trans	501..700	CDD:278921	96/207 (46%)
		Ion_trans_2	613..696	CDD:285168	45/91 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820