DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	273	Identity:	100/273 - (36%)
Similarity:	146/273 - (53%)	Gaps:	26/273 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 PRN-----------CSDCVCGIANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLL 163
            |||           ||:  ||...:..||||||.....::||.|.:..|.|..|..|:|..::::
Human   192 PRNNCTSGQVVSLRCSE--CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVV 254

  Fly   164 TASHCVYGFRKERIS-----VRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDE 223
            ||:||::.||..|:|     ..|:.|.....|...:   |..:|.||.|:|:|:|.|:|:::|..
Human   255 TAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGAL---VERIIPHPLYSAQNHDYDVALLRLQT 316

  Fly   224 PVEFNEVLHPVCMPTPGRSF-KGENGIVTGWGALKVGGP-TSDTLQEVQVPILSQDECRKS-RYG 285
            .:.|::.:..||:|...:.| ||....|:|||....... :||.||:..||:.|...|..| .|.
Human   317 ALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYS 381

  Fly   286 NKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRY 350
            ..:|..|||.||.:|..|:|||||||||  |.......::.||||||.|||:..:|||||:|..:
Human   382 GALTPRMLCAGYLDGRADACQGDSGGPL--VCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEF 444

  Fly   351 GTWIKNLTKQACL 363
            ..||.:..:.:.|
Human   445 LDWIHDTAQDSLL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	90/235 (38%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	91/236 (39%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	7/22 (32%)
		Tryp_SPc	217..448	CDD:214473	90/235 (38%)
		Tryp_SPc	218..451	CDD:238113	91/237 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960