DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and prss60.1

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001082915.1	Gene:	prss60.1 / 799770	ZFINID:	ZDB-GENE-070424-25	Length:	387	Species:	Danio rerio

Alignment Length:	250	Identity:	92/250 - (36%)
Similarity:	141/250 - (56%)	Gaps:	9/250 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 VCGIANIQKRIVGGQETEVHQYPWVAML---LYGGRFYCAASLLNDQFLLTASHCVYGFRKERIS 178
            |||:|.:..|||||.......:||...|   :|||.| |..||:|.:::|||:||:.......:.
Zfish    24 VCGLAPLNNRIVGGVNAFDGSWPWQVSLHSPIYGGHF-CGGSLINSEWVLTAAHCLPRITTSSLL 87

  Fly   179 VRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSF 243
            |.|.:..::..:..:|:|.|:.:..||.||....:||||::.|...|.|:..:.|||:......|
Zfish    88 VFLGKTTQQGVNTYEINRTVSVITVHPSYNNLTNENDIALLHLSSAVTFSNYIRPVCLAAQNSVF 152

  Fly   244 -KGENGIVTGWGALKVGG--PTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSC 305
             .|.:..:||||.:::|.  |....|||..:|::..|:|........:|:||:|.|..:||:|:|
Zfish   153 PNGTSSWITGWGNIQLGVNLPAPGILQETMIPVVPNDQCNALLGSGSVTNNMICAGLLQGGRDTC 217

  Fly   306 QGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTKQ 360
            |||||||:  |:........:|:.|||.|||....||||.||::|.:||.::..|
Zfish   218 QGDSGGPM--VSKQCLVWVQSGITSWGYGCADPYSPGVYTRVSQYQSWINSIIVQ 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	85/233 (36%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	86/234 (37%)
prss60.1	NP_001082915.1	Tryp_SPc	33..264	CDD:214473	85/233 (36%)
		Tryp_SPc	34..267	CDD:238113	86/235 (37%)
		Somatomedin_B	349..382	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587867
Domainoid	1	1.000	191	1.000	Domainoid score	I3175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3731
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6349
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.790