DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	309	Identity:	103/309 - (33%)
Similarity:	150/309 - (48%)	Gaps:	44/309 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SSSSMMPDAASTTSTTTPAPSSSTTTTRRATTPAPPTLNPPRNCSD-------CV-CGI---ANI 123
            ||..::.|:.||        |.....|..........|.....||.       |: ||:   ::.
Human   233 SSQGIVDDSGST--------SFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSR 289

  Fly   124 QKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRKERISVRLLEHDRKM 188
            |.|||||:......:||...|.......|..|::..::::||:|||         .:.|.:....
Human   290 QSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCV---------EKPLNNPWHW 345

  Fly   189 SHMQKIDR----------KVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSF 243
            :....|.|          :|.:||:||.|:::..:||||::||.:|:.||:::.|||:|.||...
Human   346 TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMML 410

  Fly   244 KGENGI-VTGWGALKVGGPTSDTLQEVQVPILSQDECRKSR--YGNKITDNMLCGGYDEGGKDSC 305
            :.|... ::||||.:..|.||:.|...:|.::....| .||  |.|.||..|:|.|:.:|..|||
Human   411 QPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC-NSRYVYDNLITPAMICAGFLQGNVDSC 474

  Fly   306 QGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWI 354
            ||||||||  |.|......:.|..|||.|||||..||||..|..:..||
Human   475 QGDSGGPL--VTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	87/240 (36%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	88/241 (37%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133	12/57 (21%)
		Tryp_SPc	292..521	CDD:214473	87/240 (36%)
		Tryp_SPc	293..524	CDD:238113	88/241 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8579
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860