DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	237	Identity:	94/237 - (39%)
Similarity:	131/237 - (55%)	Gaps:	16/237 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 RIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGF---RKERISVRL--LEHD 185
            |||||..:.:.|:||.|.|.:.|...|..|::...:::||:||||..   :...|.|.|  |..:
Human   216 RIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDN 280

  Fly   186 RKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSF-KGENGI 249
            ...||:      |.:::.|.||..:...||||::||..|:.|||::.|||:|....:| .|:...
Human   281 PAPSHL------VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCW 339

  Fly   250 VTGWGALKVG-GPTSDTLQEVQVPILSQDEC-RKSRYGNKITDNMLCGGYDEGGKDSCQGDSGGP 312
            .:||||.:.| |..|..|....||::|...| .:..||..|:.:|||.||..||.||||||||||
Human   340 TSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGP 404

  Fly   313 LHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWI 354
            |  |....|..::.|..|:|.|||:...||||.||..:..||
Human   405 L--VCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	92/235 (39%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	93/236 (39%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133
		Tryp_SPc	216..444	CDD:214473	92/235 (39%)
		Tryp_SPc	217..447	CDD:238113	93/236 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860