Protein Alignment tpr and PRSS22

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: XP_054169579.1
• Gene: PRSS22 / 64063
• HGNCID: 14368
• Length: 425
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 92/280 - (32%)
• Similarity: 150/280 - (53%)
• Gaps: 27/280 - (9%)

  Fly    98 RATTPAPPT-LNPPRNCSDCVCGIANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQF 161
            ||...:||. ||..|......||......|:|||:::...::||:..:...|..:||.|||..::
Human   128 RARGSSPPAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRW 192

  Fly   162 LLTASHCVYGFRKERISVRLL--------EHDRKMSHMQKIDRKVAEVITHPKYN-ARNYDNDIA 217
            ::||:||.    |:.::...|        :.....|..||:.  ||.|..||.|: ......|||
Human   193 VITAAHCF----KDNLNKPYLFSVLLGAWQLGNPGSRSQKVG--VAWVEPHPVYSWKEGACADIA 251

  Fly   218 IIKLDEPVEFNEVLHPVCMPTPGRSFKGENGI-VTGWGALKVGGPT--SDTLQEVQVPILSQDEC 279
            :::|:..::|:|.:.|:|:|............ ::|||:::.|.|.  ..|||:::|||:..:.|
Human   252 LVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVC 316

  Fly   280 -----RKSRYGNKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAG 339
                 |.:..| .||::|||.||.||.:|:|.|||||||.....|.  ..:||::|||||||:..
Human   317 SHLYWRGAGQG-PITEDMLCAGYLEGERDACLGDSGGPLMCQVDGA--WLLAGIISWGEGCAERN 378

  Fly   340 YPGVYARVNRYGTWIKNLTK 359
            .||||..::.:.:|::.:.:
Human   379 RPGVYISLSAHRSWVEKIVQ 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	82/245 (33%)
PRSS22	XP_054169579.1	Tryp_SPc	158..396	CDD:238113	82/246 (33%)