Protein Alignment tpr and F12

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_067464.2
• Gene: F12 / 58992
• MGIID: 1891012
• Length: 597
• Species: Mus musculus
• Alignment Length: 326
• Identity: 106/326 - (32%)
• Similarity: 152/326 - (46%)
• Gaps: 51/326 - (15%)

  Fly    57 GSSDSENATLATLSSSSMMPDAASTTSTTTPAPSSST---TTTRRATTPAPPTLNPPRNCSDCVC 118
            |....:..|.|.|.......::.|...:.:.||:.||   |:..:..|..              |
Mouse   291 GLEQCQTPTFAPLVVPESQEESPSQAPSLSHAPNDSTDHQTSLSKTNTMG--------------C 341

  Fly   119 GIANIQK------RIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGF-RKER 176
            | ...:|      |:|||.......:|::|.|.:|..| ||.||:...::|||:||:... ..|.
Mouse   342 G-QRFRKGLSSFMRVVGGLVALPGSHPYIAALYWGNNF-CAGSLIAPCWVLTAAHCLQNRPAPEE 404

  Fly   177 ISVRLLEHDRKMSHMQKID----RKVAEVITHPKYNARNYDNDIAIIKLDEP-----VEFNEVLH 232
            ::| :|..||   |.|..:    ..|.....|..:::..|.:|:|:::|.|.     ...:..:.
Mouse   405 LTV-VLGQDR---HNQSCEWCQTLAVRSYRLHEGFSSITYQHDLALLRLQESKTNSCAILSPHVQ 465

  Fly   233 PVCMPT----PGRSFKGENGIVTGWGALKVGGPTSDT-LQEVQVPILSQDECRKSR-YGNKITDN 291
            |||:|:    |..:...|   |.|||....|.....| |||.|||.::.|.|..|. :|:.|...
Mouse   466 PVCLPSGAAPPSETVLCE---VAGWGHQFEGAEEYSTFLQEAQVPFIALDRCSNSNVHGDAILPG 527

  Fly   292 MLCGGYDEGGKDSCQGDSGGPLHIVASGTREHQIA--GVVSWGEGCAKAGYPGVYARVNRYGTWI 354
            |||.|:.|||.|:||||||||| :...||.|||:.  ||:|||.||.....||||..|..|..||
Mouse   528 MLCAGFLEGGTDACQGDSGGPL-VCEEGTAEHQLTLRGVISWGSGCGDRNKPGVYTDVANYLAWI 591

  Fly   355 K 355
            :
Mouse   592 Q 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	91/247 (37%)
F12	NP_067464.2	FN2	41..88	CDD:238019
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:394967
		KR	217..295	CDD:412161	1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..338		6/31 (19%)
		Tryp_SPc	355..594	CDD:238113	91/247 (37%)