Protein Alignment tpr and TMPRSS4

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: XP_005271670.1
• Gene: TMPRSS4 / 56649
• HGNCID: 11878
• Length: 494
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 109/369 - (29%)
• Similarity: 166/369 - (44%)
• Gaps: 59/369 - (15%)

  Fly    17 GPSQSA--SQDRATNQTAASPLLKQSQNTFIQWVLSLLPQRPGSSDSENAT--LATLSSSSMMPD 77
            ||:.:.  |:||:|.|...|    .:.|.|             |:..:|.|  ||..:...|...
Human    99 GPAVAVRLSKDRSTLQVLDS----ATGNWF-------------SACFDNFTEALAETACRQMGYS 146

  Fly    78 AASTTSTTTPAPS--------SSTTTTRRATTPAPPTLNPPRNCSDCV-CGIANIQKRIVGGQET 133
            :..|.......|.        :..:...|....:.|.|:.......|: ||.:....|:||.:|.
Human   147 SKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEA 211

  Fly   134 EVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRK--ERISVRLLEHDRKMSHMQKIDR 196
            .|..:||...:.|..:..|..|:|:..::|||:||   |||  :..:.::.....|:.....:
Human   212 SVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC---FRKHTDVFNWKVRAGSDKLGSFPSL-- 271

  Fly   197 KVAEVIT---HPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMP------TPGRSFKGENGIVTG 252
            .||::|.   :|.|..   |||||::||..|:.|:..:.|:|:|      ||....     .:.|
Human   272 AVAKIIIIEFNPMYPK---DNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPL-----WIIG 328

  Fly   253 WGALKV-GGPTSDTLQEVQVPILSQDECR-KSRYGNKITDNMLCGGYDEGGKDSCQGDSGGPLHI 315
            ||..|. ||..||.|.:..|.::....|. ...|..::|:.|:|.|..|||.|:|||||||||..
Human   329 WGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMY 393

  Fly   316 VASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTK 359
            .:.   :..:.|:||||.||.....||||.:|:.|..||.|:.|
Human   394 QSD---QWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	82/241 (34%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:470597	19/105 (18%)
		Tryp_SPc	204..429	CDD:214473	81/240 (34%)