DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and PRSS1

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	362	Identity:	124/362 - (34%)
Similarity:	178/362 - (49%)	Gaps:	56/362 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GPS------QSASQDRATNQTAASPLLKQSQNTFIQWV-LSLLPQRPGSSDSEN----ATLATLS 70
            ||:      |..|......:.:.||:..:.:    :|. ::.|.|.||...:..    ..:.||:
Human   139 GPAKYPCRKQPVSLSALRRKVSLSPVNHKPR----EWPNIARLMQDPGKRKAAGVFVLGGVVTLT 199

  Fly    71 SSS-------MMPDAASTTS---TTTPAPSSSTTTTRRATTPAPPTLNPPRNCSDCVCGIANIQK 125
            |.|       ...|.:||||   :||..|....|....|       |..|.:..|
Human   200 SQSPPLWILVRYKDESSTTSQAHSTTMNPLLILTFVAAA-------LAAPFDDDD---------- 247

  Fly   126 RIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRKERISVRLLEHDRKMSH 190
            :||||...|.:..|: .:.|..|..:|..||:|:|::::|.||.    |.||.|||.||:.::..
Human   248 KIVGGYNCEENSVPY-QVSLNSGYHFCGGSLINEQWVVSAGHCY----KSRIQVRLGEHNIEVLE 307

  Fly   191 MQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSFKGENGIVTGWG- 254
            ..:.....|::|.||:|:.:..:|||.:|||......|..:..:.:||...: .|...:::|||
Human   308 GNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPA-TGTKCLISGWGN 371

  Fly   255 ALKVGGPTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASG 319
            ....|....|.||.:..|:|||.:|..| |..|||.||.|.|:.||||||||||||||  :|.:|
Human   372 TASSGADYPDELQCLDAPVLSQAKCEAS-YPGKITSNMFCVGFLEGGKDSCQGDSGGP--VVCNG 433

  Fly   320 TREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKN 356
                |:.||||||:|||:...||||.:|..|..||||
Human   434 ----QLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKN 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	92/228 (40%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	94/229 (41%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	92/228 (40%)
		Tryp_SPc	249..467	CDD:238113	96/231 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810