DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and prss60.2

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001099071.1	Gene:	prss60.2 / 541408	ZFINID:	ZDB-GENE-050320-109	Length:	328	Species:	Danio rerio

Alignment Length:	253	Identity:	96/253 - (37%)
Similarity:	141/253 - (55%)	Gaps:	15/253 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 VCGIANIQKRIVGGQETEVHQYPWVAML---LYGGRFYCAASLLNDQFLLTASHCVYGFRKERIS 178
            |||.|.:..|||||.......:||...|   .|||.| |..||::.:::|||:||:.|..:..:.
Zfish    24 VCGQAPLNSRIVGGVNAPEGSWPWQVSLQSPRYGGHF-CGGSLISSEWVLTAAHCLPGVSESSLV 87

  Fly   179 VRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSF 243
            |.|....::..:..:..|.||::|.|..||:...|||||:::|...|.||:.:.|||:......:
Zfish    88 VYLGRRTQQGVNTHETSRNVAKIIVHSSYNSNTNDNDIALLRLSSAVTFNDYIRPVCLAAQNSVY 152

  Fly   244 K-GENGIVTGWGALKVGG--PTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSC 305
            . |.:..:||||.::.|.  |....|||..:|:::.|.|........:|:||:|.|..:||||:|
Zfish   153 SAGTSSWITGWGDVQAGVNLPAPGILQETMIPVVANDRCNAQLGSGTVTNNMICAGLAKGGKDTC 217

  Fly   306 QGDSGGPLHIVASGTREHQI---AGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTKQ 360
            |||||||:     .||...:   ||:.|||.|||....||||.||::|.:||.:...|
Zfish   218 QGDSGGPM-----VTRLCTVWIQAGITSWGYGCADPNSPGVYTRVSQYQSWISSKISQ 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	89/236 (38%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	90/237 (38%)
prss60.2	NP_001099071.1	Tryp_SPc	33..264	CDD:214473	89/236 (38%)
		Tryp_SPc	34..267	CDD:238113	90/238 (38%)
		Somatomedin_B	296..326	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587865
Domainoid	1	1.000	191	1.000	Domainoid score	I3175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3731
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6349
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.790