Protein Alignment tpr and KLK12

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_062544.1
• Gene: KLK12 / 43849
• HGNCID: 6360
• Length: 254
• Species: Homo sapiens
• Alignment Length: 249
• Identity: 81/249 - (32%)
• Similarity: 118/249 - (47%)
• Gaps: 26/249 - (10%)

  Fly   116 CVCGIAN-IQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRKERISV 179
            ||.|::. ...:|..|.|...:..||...|..|....|...|::.:::|||:||    ...|..|
Human    10 CVLGLSQAATPKIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAHC----SGSRYWV 70

  Fly   180 RLLEHDRKMSHMQKIDRKVAEVITHPKY--NARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRS 242
            ||.||........:..|.....:|||.|  .:.::::|:.:::|..||.....:.|:.:|....:
Human    71 RLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTSSVQPLPLPNDCAT 135

  Fly   243 FKGENGIVTGWGALK-VGGPTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSCQ 306
             .|....|:|||... ...|..|.||.:.:.|:|...|. ..|..:||.||:|.| ...|:|:||
Human   136 -AGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATCH-GVYPGRITSNMVCAG-GVPGQDACQ 197

  Fly   307 GDSGGPLHIVASGTREHQIAGVVSWGE--GCAKAGYPGVYARVNRYGTWIKNLT 358
            |||||||  |..|.    :.|:||||.  .|.:.|.||||       |:|.|.|
Human   198 GDSGGPL--VCGGV----LQGLVSWGSVGPCGQDGIPGVY-------TYICNST 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	76/233 (33%)
KLK12	NP_062544.1	Tryp_SPc	22..236	CDD:238113	76/233 (33%)