DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and Tmprss11c

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001025468.1	Gene:	Tmprss11c / 435845	MGIID:	3521861	Length:	431	Species:	Mus musculus

Alignment Length:	259	Identity:	88/259 - (33%)
Similarity:	131/259 - (50%)	Gaps:	35/259 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 CGIANIQKR---IVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCV---------- 169
            ||...|..|   :.|||:.|..::||.|.|.......|.|:|:::.:|:||:||.
Mouse   188 CGRRTIIHRGHKVAGGQDAEEGEWPWQASLQQNSVHRCGATLISNYWLITAAHCFIRAANPKDWK 252

  Fly   170 --YGFRKERISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLH 232
              :||               :....:..|.|..:|.|..|:...:|||||:::|..||.:...:.
Mouse   253 VSFGF---------------LLSKPQAPRAVKNIIIHENYSYPAHDNDIAVVRLSSPVLYESNIR 302

  Fly   233 PVCMPTPGRSF-KGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSR-YGNKITDNMLCG 295
            ..|:|...:.| ...:.:|||||.||..|.:.:.||:.:|.|:....|...: ||..||..|:|.
Mouse   303 RACLPEATQKFPPNSDVVVTGWGTLKSDGDSPNILQKGKVKIIDNKTCNSGKAYGGMITPGMMCA 367

  Fly   296 GYDEGGKDSCQGDSGGPLHIVASGTRE-HQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLT 358
            |:.:|..|:|||||||||  |:..::. ..:||:||||:.||....||||.||..|..||.:.|
Mouse   368 GFLKGRVDACQGDSGGPL--VSEDSKGIWFLAGIVSWGDECALPNKPGVYTRVTYYRDWITSKT 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	82/245 (33%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	83/243 (34%)
Tmprss11c	NP_001025468.1	SEA	62..157	CDD:279699
		Tryp_SPc	199..425	CDD:214473	81/242 (33%)
		Tryp_SPc	200..428	CDD:238113	83/244 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I3995
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.960