Protein Alignment tpr and LPA

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_005568.2
• Gene: LPA / 4018
• HGNCID: 6667
• Length: 2040
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 105/378 - (27%)
• Similarity: 162/378 - (42%)
• Gaps: 85/378 - (22%)

  Fly    45 IQWVLSLLPQRPGSSDSENATLA---TLSSSSMMPDA---------------ASTTSTTTPAPSS 91
            |:|....|.:   .||:|...:|   .:...|:.|.:               .:||.|.||....
Human  1683 IRWEYCNLTR---CSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEW 1744

  Fly    92 STTTTRRATTPAPPT-----------LNP-------------PRNCSD------CV-----CGIA 121
            :.....|.:|..|.|           .||             ||...|      |.     ||..
Human  1745 AAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKP 1809

  Fly   122 NIQKR-----IVGGQETEVHQYPW-VAMLLYGGRFYCAASLLNDQFLLTASHCV-YGFRKERISV 179
            .::.:     ||||.....|.:|| |::....|:.:|..:|::.:::|||:||: ...|.....|
Human  1810 QVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKV 1874

  Fly   180 RLLEHD--RKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRS 242
            .|..|.  ...||:|:|:  |:.:...|.      ..|||::||..|....:.:.|.|:|:|...
Human  1875 ILGAHQEVNLESHVQEIE--VSRLFLEPT------QADIALLKLSRPAVITDKVMPACLPSPDYM 1931

  Fly   243 FKGENG-IVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSCQ 306
            ...... .:||||..: |...:..|:|.|:.::..:.|...:|        :|..:...|.||||
Human  1932 VTARTECYITGWGETQ-GTFGTGLLKEAQLLVIENEVCNHYKY--------ICAEHLARGTDSCQ 1987

  Fly   307 GDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTK 359
            |||||||  |.....::.:.||.|||.|||:...|||||||:|:.|||:.:.:
Human  1988 GDSGGPL--VCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMR 2038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	79/233 (34%)
LPA	NP_005568.2	Kringle	28..105	CDD:395005
		Kringle	142..219	CDD:395005
		Kringle	256..333	CDD:395005
		Kringle	370..447	CDD:395005
		Kringle	484..561	CDD:395005
		Kringle	598..675	CDD:395005
		Kringle	712..789	CDD:395005
		Kringle	826..903	CDD:395005
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1166
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1365..1388
		KR	1386..1466	CDD:214527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1476..1497
		KR	1500..1581	CDD:214527
		KR	1614..1695	CDD:214527	3/14 (21%)
		Kringle	1720..1799	CDD:395005	14/78 (18%)
		Tryp_SPc	1820..2034	CDD:238113	78/232 (34%)