DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and KLKB1

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	260	Identity:	97/260 - (37%)
Similarity:	140/260 - (53%)	Gaps:	13/260 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 RNCS---DCVCGIANIQKRIVGGQETEVHQYPWVAML---LYGGRFYCAASLLNDQFLLTASHCV 169
            |.|:   :.|| ......|||||..:...::||...|   |...|..|..||:..|::|||:||.
Human   384 RLCNTGDNSVC-TTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF 447

  Fly   170 YGFRKERISVRLLEHDRKMSHMQKID--RKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLH 232
            .|...:.: .|:......:|.:.|..  .::.|:|.|..|.....::|||:|||..|:.:.|...
Human   448 DGLPLQDV-WRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQK 511

  Fly   233 PVCMPTPG-RSFKGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGG 296
            |:|:|:.| .|....|..|||||..|..|...:.||:|.:|:::.:||:|.....|||..|:|.|
Human   512 PICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAG 576

  Fly   297 YDEGGKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTKQA 361
            |.|||||:|:|||||||  |.......::.|:.|||||||:...||||.:|..|..||...|:.:
Human   577 YKEGGKDACKGDSGGPL--VCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSS 639

Fly 362 361
Human 640 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	90/233 (39%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	91/234 (39%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519	1/1 (100%)
		Tryp_SPc	401..632	CDD:214473	90/233 (39%)
		Tryp_SPc	402..632	CDD:238113	89/232 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810