Protein Alignment tpr and KLK2

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_005542.1
• Gene: KLK2 / 3817
• HGNCID: 6363
• Length: 261
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 48/269 - (17%)
• Similarity: 83/269 - (30%)
• Gaps: 90/269 - (33%)

  Fly    61 LTAANSAVP-GAPNGQPLPQSALSLSAAQQQQFLQHNAAYAAQQAPPYVINPGQDPNQY--MGAL 122
            |..:|::.| |:.:...|..|.|..|..::.   ..:.::..::....:.:.....|:|  ..:.
Human    17 LPKSNASFPWGSLDEDELDDSLLEFSDGEED---DGHFSFTEEEIEMLLKDDDGGHNEYRPRKSQ 78

  Fly   123 IAAGVPQ---YYAPAPWGVYPANLAIPQ-------------QQSQPRRPLTPSQQGAENQPY--- 168
            |...:||   .|:..|....|..|.:||             ...:...|.:..:|..|:.|.
Human    79 ILPDIPQENSLYSLGPAAETPGFLKLPQLICDPVLDKDKIDSSKETENPASLREQTREDDPQPNE 143

  Fly   169 -------QVISAYYD-----QSGSLVMGPRTGTPM--------------------RLVSPAPPVL 201
                   :.||.:.:     .|||...|.....|:                    |.:....|||
Human   144 SKRCTEPEGISNHSEVPNRKNSGSHKSGCEVRIPVVSSSSNRHAFDKDSGEAKGERRLGKVIPVL 208

  Fly   202 VPPGAAGPRAPQAPPMYPPQPQTAQQNVYSAQ--------NGSNVGGLGALNT------------ 246
                      .....|:.......|:::|.::        ..||.|.||.|:.
Human   209 ----------QTRTRMFSQSELEKQKDIYLSKVIAHIEDPGDSNQGTLGELDALMDQVHMQHPDW 263

  Fly   247 ---SSLTTR 252
               |.||||
Human   264 QHPSDLTTR 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	37/200 (19%)
KLK2	NP_005542.1	Tryp_SPc	25..256	CDD:238113	41/243 (17%)