Protein Alignment tpr and KLK1

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 93/277 - (33%)
• Similarity: 133/277 - (48%)
• Gaps: 55/277 - (19%)

  Fly   100 TTPAPPTLNPPRNCSDCVCGIANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLT 164
            |..|||                 ||.|||||.|.|.|..||.|.|.:...|.|...|::.|::||
Human    15 TGAAPP-----------------IQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLT 62

  Fly   165 ASHCV---YGFRKERISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNA-----------RNYDND 215
            |:||:   |.....|.::...|:..:..|       |:|...||.:|.           .:|.:|
Human    63 AAHCISDNYQLWLGRHNLFDDENTAQFVH-------VSESFPHPGFNMSLLENHTRQADEDYSHD 120

  Fly   216 IAIIKLDEPVE-FNEVLHPVCMPTPGRSFKGENGIVTGWGALKVGGPTS----DTLQEVQVPILS 275
            :.:::|.||.: ..:.:..|.:||..... |...:.:|||:::   |.:    |.||.|.:.||.
Human   121 LMLLRLTEPADTITDAVKVVELPTEEPEV-GSTCLASGWGSIE---PENFSFPDDLQCVDLKILP 181

  Fly   276 QDECRKSRYGNKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGTREHQIAGVVSWG-EGCAKAG 339
            .|||:|: :..|:||.|||.|:.|||||:|.|||||||  :..|.    :.||.||| ..|....
Human   182 NDECKKA-HVQKVTDFMLCVGHLEGGKDTCVGDSGGPL--MCDGV----LQGVTSWGYVPCGTPN 239

  Fly   340 YPGVYARVNRYGTWIKN 356
            .|.|..||..|..||::
Human   240 KPSVAVRVLSYVKWIED 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	86/248 (35%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	86/250 (34%)