DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and HP

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_005134.1	Gene:	HP / 3240	HGNCID:	5141	Length:	406	Species:	Homo sapiens

Alignment Length:	263	Identity:	70/263 - (26%)
Similarity:	124/263 - (47%)	Gaps:	30/263 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 DCVCG----IANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRKE 175
            :.|||    .||..:||:||.......:||.|.::........|:|:|:|:|||.:..::....|
Human   146 EAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSE 210

  Fly   176 RISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPG 240
            ..:.:.:.....:...:|...::.:|:.||.|:    ..||.:|||.:.|..||.:.|:|:|:..
Human   211 NATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICLPSKD 271

  Fly   241 RSFKGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSRYGNKI----------------T 289
            .:..|..|.|:|||. ......:|.|:.|.:|:..||:|.:...|:.:                .
Human   272 YAEVGRVGYVSGWGR-NANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILN 335

  Fly   290 DNMLCGGYDEGGKDSCQGDSGG--PLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGT 352
            ::..|.|..:..:|:|.||:|.  .:|.:...|  ....|::|:.:.||.|.| |||.:|.....
Human   336 EHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT--WYATGILSFDKSCAVAEY-GVYVKVTSIQD 397

  Fly   353 WIK 355
            |::
Human   398 WVQ 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	64/245 (26%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	64/247 (26%)
HP	NP_005134.1	CCP	33..87	CDD:153056
		CCP	92..146	CDD:153056	70/263 (27%)
		Tryp_SPc	161..399	CDD:214473	64/245 (26%)
		Tryp_SPc	162..402	CDD:238113	64/247 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910