Protein Alignment tpr and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 91/314 - (28%)
• Similarity: 150/314 - (47%)
• Gaps: 29/314 - (9%)

  Fly    63 NATLATLSSSSMMPDAASTTSTTTPAPSSSTTTTRRATTPAPPTLNPPR----NCSDCVCGIANI 123
            :..|..:.||.:..|..|.:......||.....:.:........|...|    :..|  ||.|.:
Human     7 SVALLFVGSSHLYSDHYSPSGRHRLGPSPEPAASSQQAEAVRKRLRRRREGGAHAED--CGTAPL 69

  Fly   124 Q-----KRIVGGQETEVHQYPWVAML-LYGGR---FYCAASLLNDQFLLTASHCVYGFRKERISV 179
            :     .||:||.|.:...:|||..| :..||   ..|..:|:.::::|||:||........:..
Human    70 KDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWT 134

  Fly   180 RLLE----HDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPG 240
            .::.    |.| ..|.:||  |:..:|.||.:...:|.||||:..|.:.|.:|:.:.|:|:|..
Human   135 AVIGTNNIHGR-YPHTKKI--KIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFD- 195

  Fly   241 RSFKGENG----IVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSR-YGNKITDNMLCGGYDEG 300
             .|:..:|    .::|||..|..|..::.||:.:|..:|::.|...| ||..|.:...|.|.::|
Human   196 -VFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDEDG 259

  Fly   301 GKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWI 354
            ..|:|:|||||||.......:...:.|:.|:|.||.:.|:||||...:.|..|:
Human   260 AFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	77/241 (32%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		3/21 (14%)
		Tryp_SPc	78..316	CDD:238113	77/241 (32%)