DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tpr and Tmprss11e

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_766468.1	Gene:	Tmprss11e / 243084	MGIID:	3513175	Length:	423	Species:	Mus musculus

Alignment Length:	276	Identity:	99/276 - (35%)
Similarity:	145/276 - (52%)	Gaps:	26/276 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PPTLNPPR------------NCSDCVCGI----ANIQK--RIVGGQETEVHQYPWVAMLLYGGRF 150
            ||.::|..            |..:..||.    :.:|.  |||||...|..::||.:.|.:.|..
Mouse   151 PPNVDPESVKIKKINKTESDNYFNHCCGTRRNKSTVQTSVRIVGGTPVEEEEWPWQSSLRWDGSH 215

  Fly   151 YCAASLLNDQFLLTASHCVYGFRKERISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDND 215
            .|.|:|:|:.:|:||:||   ||..:...|...........:|:...:..:|.|.||...::|.|
Mouse   216 RCGATLINNTWLVTAAHC---FRTHKDPSRWSATFGATLQPRKLTTGIRRIIVHEKYKYPSHDYD 277

  Fly   216 IAIIKLDEPVEFNEVLHPVCMPTPGRSFK-GENGIVTGWGALKVGGPTSDTLQEVQVPILSQDEC 279
            ||:.:|.:||.....:|.||:|.....|: |:...|||:||||..|.|.:.|::|||..:....|
Mouse   278 IALAELSKPVPCTNAVHKVCLPDANHEFQPGQRMFVTGFGALKNDGFTQNNLRQVQVDYIDTQTC 342

  Fly   280 RKSR-YGNKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGTRE-HQIAGVVSWGEGCAKAGYPG 342
            .:.: |...||..|||.|:.:|.||:|||||||||  |.:..|: ..:|||||||:.|.:...||
Mouse   343 NQPQSYNGAITPRMLCAGFLKGEKDACQGDSGGPL--VTADVRDIWYLAGVVSWGDECGQPNKPG 405

  Fly   343 VYARVNRYGTWIKNLT 358
            ||.||..:..||.:.|
Mouse   406 VYTRVTAFRHWIASNT 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	89/230 (39%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	90/231 (39%)
Tmprss11e	NP_766468.1	SEA	50..145	CDD:279699
		Tryp_SPc	191..417	CDD:214473	89/230 (39%)
		Tryp_SPc	192..420	CDD:238113	90/232 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I3995
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960