Protein Alignment tpr and F10

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_000495.1
• Gene: F10 / 2159
• HGNCID: 3528
• Length: 488
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 101/335 - (30%)
• Similarity: 161/335 - (48%)
• Gaps: 44/335 - (13%)

  Fly    60 DSENATLATLSSSSMMPDAASTTSTTTPAPSSSTTTTRRATTPAPPT------------------ 106
            :.:|:.:.:.:....:.|.......|.|.|....|..||..:.|..|
Human   142 EEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAA 206

  Fly   107 -LNPPRNCSDCV--------CGIANIQKRIVGGQETEVHQYPWVAMLL-YGGRFYCAASLLNDQF 161
             |:|..|..|.:        .|..|: .|||||||.:..:.||.|:|: .....:|..::|::.:
Human   207 DLDPTENPFDLLDFNQTQPERGDNNL-TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFY 270

  Fly   162 LLTASHCVYGFRKERISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVE 226
            :|||:||:|  :.:|..||:.:.:.:.....:...:|..||.|.::....||.|||:::|..|:.
Human   271 ILTAAHCLY--QAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPIT 333

  Fly   227 FNEVLHPVCMP----TPGRSFKGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSRYGNK 287
            |...:.|.|:|    ........:.|||:|:|.....|..|..|:.::||.:.::.|:.|. ...
Human   334 FRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSS-SFI 397

  Fly   288 ITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGTR---EHQIAGVVSWGEGCAKAGYPGVYARVNR 349
            ||.||.|.|||...:|:|||||||| |:    ||   .:.:.|:||||||||:.|..|:|.:|..
Human   398 ITQNMFCAGYDTKQEDACQGDSGGP-HV----TRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTA 457

  Fly   350 YGTWIKNLTK 359
            :..||....|
Human   458 FLKWIDRSMK 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	83/236 (35%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:464251	2/21 (10%)
		O-glycosylated at one site	183..203		2/19 (11%)
		Tryp_SPc	235..464	CDD:238113	83/236 (35%)
		O-glycosylated at one site	476..485