Protein Alignment tpr and F9

DIOPT Version :10

• Sequence 1: NP_611611.1
• Gene: tpr / 37486
• FlyBaseID: FBgn0034661
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_000124.1
• Gene: F9 / 2158
• HGNCID: 3551
• Length: 461
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 103/324 - (31%)
• Similarity: 170/324 - (52%)
• Gaps: 34/324 - (10%)

  Fly    59 SDSENATLATLSSSSMMPDAASTTSTTTPAPS-----SSTTTTRRATTPAPPTLNPPRNCSDCVC 118
            :.::|..:.:.:....:.:...:.....|.|.     |.|:...||.|..|..  ...|.::...
Human   147 NSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDV--DYVNSTEAET 209

  Fly   119 GIANIQK---------RIVGGQETEVHQYPWVAMLLYGGRF--YCAASLLNDQFLLTASHCVYGF 172
            .:.||.:         |:|||::.:..|:||..:|  .|:.  :|..|::|:::::||:|||.
Human   210 ILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVL--NGKVDAFCGGSIVNEKWIVTAAHCVE-- 270

  Fly   173 RKERISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNA--RNYDNDIAIIKLDEPVEFNEVLHPVC 235
            ...:|:|...||:.:.:...:..|.|..:|.|..|||  ..|::|||:::||||:..|..:.|:|
Human   271 TGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPIC 335

  Fly   236 MPTPGRS---FKGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSRYGNKIT--DNMLCG 295
            :.....:   .|..:|.|:|||.:...|.::..||.::||::.:..|.:|   .|.|  :||.|.
Human   336 IADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRS---TKFTIYNNMFCA 397

  Fly   296 GYDEGGKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTK 359
            |:.|||:||||||||||......||  ..:.|::||||.||..|..|:|.:|:||..|||..||
Human   398 GFHEGGRDSCQGDSGGPHVTEVEGT--SFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	87/237 (37%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011
		FXa_inhibition	134..170	CDD:464251	1/22 (5%)
		Tryp_SPc	227..457	CDD:238113	88/238 (37%)