DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	296	Identity:	100/296 - (33%)
Similarity:	154/296 - (52%)	Gaps:	51/296 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PAPPTLNPPRNCSD------CVCGIANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQ 160
            |.|.....| :|.|      |.||:.....|||||..:...::||.|.|...||..|..:|:.|:
Human   538 PNPQCDGRP-DCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADR 601

  Fly   161 FLLTASHCVYGFRKERISVRLL---------EHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDI 216
            :::||:||   |:::.::..:|         ::.|...   ::..||:.::.||.:...::|.|:
Human   602 WVITAAHC---FQEDSMASTVLWTVFLGKVWQNSRWPG---EVSFKVSRLLLHPYHEEDSHDYDV 660

  Fly   217 AIIKLDEPVEFNEVLHPVCMPTPGRSFKGENGI---VTGWGALKVGG------------------ 260
            |:::||.||..:..:.|||:  |.||...|.|:   :||||||:.|.
Human   661 ALLQLDHPVVRSAAVRPVCL--PARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSE 723

  Fly   261 ----PTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGTR 321
                |.|:.||:|.|.::.||.|.:. |..::|..|||.||.:|.||:|||||||||...|...|
Human   724 TCCCPISNALQKVDVQLIPQDLCSEV-YRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGR 787

  Fly   322 EHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNL 357
            .. :||:||||.||.:..|.|||.|:....:||:.:
Human   788 WF-LAGLVSWGLGCGRPNYFGVYTRITGVISWIQQV 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	90/261 (34%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	91/262 (35%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486	5/19 (26%)
		Tryp_SPc	568..822	CDD:238113	91/263 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJ04
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40976
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8078
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740