DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and Tmprss3

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001157248.1	Gene:	Tmprss3 / 140765	MGIID:	2155445	Length:	475	Species:	Mus musculus

Alignment Length:	250	Identity:	95/250 - (38%)
Similarity:	134/250 - (53%)	Gaps:	18/250 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 CSDCVCGI-ANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGF---R 173
            ||  .||. .....|||||..:.:.|:||...|.:.|...|..|::...:::||:||||..   :
Mouse   226 CS--ACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHPK 288

  Fly   174 KERISVRL--LEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCM 236
            ...:.|.|  |......||:      |.::|.|.||..:...||||::||.||:.|:|.:.|:|:
Mouse   289 SWTVQVGLVSLMDSPVPSHL------VEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETIQPICL 347

  Fly   237 PTPGRSF-KGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDEC-RKSRYGNKITDNMLCGGYDE 299
            |....:| .|:....:||||.:.||..|..|....||::|...| .:..||..|:.:|||.||.:
Mouse   348 PNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLK 412

  Fly   300 GGKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWI 354
            ||.|||||||||||  |....|..::.|..|:|.|||:...||||.|:..:..||
Mouse   413 GGVDSCQGDSGGPL--VCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWI 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	89/234 (38%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	89/234 (38%)
Tmprss3	NP_001157248.1	LDLa	96..129	CDD:238060
		SRCR_2	134..233	CDD:292133	4/8 (50%)
		Tryp_SPc	238..465	CDD:214473	89/234 (38%)
		Tryp_SPc	239..468	CDD:238113	89/234 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11120
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810