DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tpr and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	370	Identity:	113/370 - (30%)
Similarity:	174/370 - (47%)	Gaps:	49/370 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QSASQDRATN--QTAASPLLKQSQNTFI------QWVLSLLPQRPGSS----------DSENATL 66
            ::|:...:||  :...:.:|...||:.|      ..|:.|||...||:          .:|..::
Human    63 ENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQLKFKFPPAEGVSM 127

  Fly    67 ATLSSSSMMPDAASTTSTTTPAPSS------STTTTRRATTPAPPTLNPPRNCSDCVCG--IAN- 122
            .|...:.:.....:..::....|:|      |...:...|          .||    ||  :||
Human   128 RTKIKAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLT----------NNC----CGRQVANS 178

  Fly   123 --IQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASHCVYGFRKERISVRLLEHD 185
              ...:||.|:.:....:||.|.:.:.||.||.|||::.::||:|:||   |.|:..|.....:.
Human   179 IITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHC---FAKKNNSKDWTVNF 240

  Fly   186 RKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSF-KGENGI 249
            ..:.:...:.|||..:|.|..|::....:|||:::|.|.|.|.|.:..:|:|...... :.:|.:
Human   241 GIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVV 305

  Fly   250 VTGWGALKVGGPTSDTLQEVQVPILSQDECRKS-RYGNKITDNMLCGGYDEGGKDSCQGDSGGPL 313
            |||||.|.:.|.....|||..:.|:....|..| .|...:||.|||.|:..|..|:||.||||||
Human   306 VTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPL 370

  Fly   314 HIVASGTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLT 358
            ....|....| :.|:||||:||.|...||||.||..|..||.:.|
Human   371 AYPDSRNIWH-LVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKT 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	85/229 (37%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	87/230 (38%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699	15/79 (19%)
		Tryp_SPc	184..410	CDD:214473	85/229 (37%)
		Tryp_SPc	185..413	CDD:238113	87/231 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380103at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41415
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920