DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Loxl2 and Loxl2

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006519807.1	Gene:	Loxl2 / 94352	MGIID:	2137913	Length:	783	Species:	Mus musculus

Alignment Length:	494	Identity:	194/494 - (39%)
Similarity:	272/494 - (55%)	Gaps:	52/494 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IHMADAVVQHRSLEDARQERQRLVHRYTKVLNKEEGAIRLVGGDNEYEGNIEVLHNGKWGAVCDD 88
            |...|...:.|......|:|          ::.::..:||.||....||.:|||.||:||.:|||
Mouse   309 IFSPDGPSRFRKAYKPEQDR----------VSPQQPLVRLRGGAQVGEGRVEVLKNGEWGTICDD 363

  Fly    89 EWDSTEADIVCRQLGFPGMRRYTRSGFFGPARRRFWMDNLFCEGHEQELVDCHF--EGWGENDCE 151
            :||...|.:|||:|||...:........|.......::.:.|.|.|:.::||.|  |..|   |.
Mouse   364 KWDLVSASVVCRELGFGTAKEAITGSRLGQGIGPIHLNEVQCTGTEKSIIDCKFNTESQG---CN 425

  Fly   152 PGEAAGVVCYPPENALIPMATPIIRDEDLPKYPIHSRSRLYVRLRGGRSRIEGRVEVSLDGGR-- 214
            ..|.|||.|                  ::|......:    |||.|||:..||||||..:...
Mouse   426 HEEDAGVRC------------------NIPIMGFQKK----VRLNGGRNPYEGRVEVLTERNGSL 468

  Fly   215 -WGSVCADGWSLLEANVVCRQLGLGYASEAFQTDFF--GGFNVSRPVLSGSECYGNETELADCLH 276
             ||:||...|.::||.|||||||||:||.|||..::  |....:..|:||.:|.|.|..||.|.|
Mouse   469 VWGTVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGNIFANNVVMSGVKCSGTELSLAHCRH 533

  Fly   277 HDASQGIISC-HGNRQHVAAVICDYIAPDLVVDYLEIEQTAHLEDRPMLLMQCAMEENCVANEAY 340
            .:.    ::| .|..:..|.|.|...|||||::...::|||:||||||.|:||||||||::..|.
Mouse   534 DEE----VACPEGGVRFGAGVACSETAPDLVLNAEIVQQTAYLEDRPMSLLQCAMEENCLSASAV 594

  Fly   341 QIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPFKEKSQWEWHMCHMHFHSMEVFATFDIFNLRG 405
            .......|     ||||:|::...|.|.:||||...:..|.||.||.|:||||||..:|:.:|.|
Mouse   595 HTDPTRGH-----RRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTYYDLLSLNG 654

  Fly   406 IKVAQGHKASFCLEDSNCLPGVAKKYNCANYGDQGISINCSDVYLYNLDCQWVDVTDLIPGTYVL 470
            .|||:||||||||||:.|...:.|.|.|||:|:|||::.|.|:|.:::||||:|:||:.||.|:.
Mouse   655 TKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWIDITDVPPGDYLF 719

  Fly   471 KIAINPEFKVAEMNYDNNAAICDLIYTANFARVQNCQLG 509
            ::.|||.::|.|.::.||...|...|......:.||.:|
Mouse   720 QVVINPNYEVPESDFSNNIMKCRSRYDGYRIWMYNCHVG 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	39/101 (39%)
		SRCR	66..160	CDD:278931	36/95 (38%)
		SR	193..298	CDD:214555	48/110 (44%)
		SRCR	198..298	CDD:278931	44/105 (42%)
		Lysyl_oxidase	303..503	CDD:279521	95/199 (48%)
Loxl2	XP_006519807.1	SR	61..162	CDD:214555
		SR	204..304	CDD:214555
		SR	336..435	CDD:214555	34/100 (34%)
		SR	445..553	CDD:214555	41/112 (37%)
		Lysyl_oxidase	557..757	CDD:366506	95/200 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2544
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1742
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2084
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	1	1.000	-	-		otm43741
orthoMCL	1	0.900	-	-		OOG6_104333
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5813
SonicParanoid	1	1.000	-	-		X896
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860