DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and CD6

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_006716.3	Gene:	CD6 / 923	HGNCID:	1691	Length:	668	Species:	Homo sapiens

Alignment Length:	328	Identity:	99/328 - (30%)
Similarity:	134/328 - (40%)	Gaps:	95/328 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VVQHRSLEDARQERQRLVHRYTKVLNKEEGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTE 94
            ||:|....|.|:.|         |...|..|:|||.|.....|.:|:|.:|:||:||||.||..:
Human   139 VVEHACRSDGRRAR---------VTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLED 194

  Fly    95 ADIVCRQLG-------FPGMRRYTRSGFFGPARRRFWMDNLFCEGHEQELVDCHFEGW-GENDCE 151
            |.:||||||       .||:.       |.|.|.....|.:.|.|.|..|.||  .|. |::.|.
Human   195 AHVVCRQLGCGWAVQALPGLH-------FTPGRGPIHRDQVNCSGAEAYLWDC--PGLPGQHYCG 250

  Fly   152 PGEAAGVVCYPPENALIPMATPIIRDEDLPKYPIHSRSRLYVRLRGGRSRIEGRVEVSLDGGRWG 216
            ..|.||.||...::                           .||.||..|.||:|||.. .|.|.
Human   251 HKEDAGAVCSEHQS---------------------------WRLTGGADRCEGQVEVHF-RGVWN 287

  Fly   217 SVCADGWSLLEANVVCRQLGLGYASEAFQTDFFGGFNVSRP-----VLSGS---ECYGNETELAD 273
            :||...|...||.|:|:.||.|.|             |.||     .|||.   .|.|.|..|::
Human   288 TVCDSEWYPSEAKVLCQSLGCGTA-------------VERPKGLPHSLSGRMYYSCNGEELTLSN 339

  Fly   274 CLHHDASQGIISCHGNRQHVAA-VIC-------DYIAPDL--VVDYLEIEQTA-----HLEDRPM 323
            |.....:..:.|     |.:|| |:|       :...|::  .|..:.||.:.     :.|.|.:
Human   340 CSWRFNNSNLCS-----QSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESREL 399

  Fly   324 LLM 326
            :|:
Human   400 MLL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	42/107 (39%)
		SRCR	66..160	CDD:278931	38/101 (38%)
		SR	193..298	CDD:214555	39/113 (35%)
		SRCR	198..298	CDD:278931	36/108 (33%)
		Lysyl_oxidase	303..503	CDD:279521	7/31 (23%)
CD6	NP_006716.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..37
		SRCR	50..156	CDD:278931	7/25 (28%)
		SR	161..260	CDD:214555	42/107 (39%)
		SRCR	166..260	CDD:278931	39/102 (38%)
		SR	265..361	CDD:214555	39/114 (34%)
		SRCR	270..361	CDD:278931	36/109 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156676
Domainoid	1	1.000	104	1.000	Domainoid score	I6689
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930