DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and CD5

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_055022.2	Gene:	CD5 / 921	HGNCID:	1685	Length:	495	Species:	Homo sapiens

Alignment Length:	149	Identity:	43/149 - (28%)
Similarity:	56/149 - (37%)	Gaps:	50/149 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LVHRYTKVLNKEEGAI--------------RLVGGDNEYEGNIEVLHNGKWGAVCDD-------E 89
            |.|.:.|:..::.|.:              |||||.:..||.:||....:|.|:||.       .
Human   247 LEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLR 311

  Fly    90 WDSTEADIVCR--QLGFPGMRRYTRSGFFGPARRRFWMDNLFCEGHEQELVDCHFEGWGEND--- 149
            |:.     |||  |.|.....|...:|  .|..|     .|||.  .|:|..|| |.|..|.
Human   312 WEE-----VCREQQCGSVNSYRVLDAG--DPTSR-----GLFCP--HQKLSQCH-ELWERNSYCK 361

  Fly   150 -----CE----PGEAAGVV 159
                 |:    .|.|||.|
Human   362 KVFVTCQDPNPAGLAAGTV 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	39/134 (29%)
		SRCR	66..160	CDD:278931	35/115 (30%)
		SR	193..298	CDD:214555
		SRCR	198..298	CDD:278931
		Lysyl_oxidase	303..503	CDD:279521
CD5	NP_055022.2	SR	36..133	CDD:214555
		SRCR	40..132	CDD:278931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..155
		SR	277..368	CDD:214555	33/105 (31%)
		SRCR	281..367	CDD:278931	29/100 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..460
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930