DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Loxl2 and LOXL4

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_005270273.1	Gene:	LOXL4 / 84171	HGNCID:	17171	Length:	757	Species:	Homo sapiens

Alignment Length:	460	Identity:	182/460 - (39%)
Similarity:	254/460 - (55%)	Gaps:	37/460 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KEEGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGFFGPAR 120
            ::|..:||..|....||.:|||.|.:||.|||..|:...|.:|||||||...|........|...
Human   307 EQEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGARLGQGL 371

  Fly   121 RRFWMDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVCYPPENALIPMATPIIRDEDLPKYPI 185
            ....:..:.|.|:|:.|.||......:|.|:....|.|.|                  ::|....
Human   372 GPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRC------------------NVPNMGF 418

  Fly   186 HSRSRLYVRLRGGRSRIEGRVEVSLDGG---RWGSVCADGWSLLEANVVCRQLGLGYASEAFQTD 247
            .::    |||.|||...||.:||.::..   ||||||::.|.|.||.|.|||||||:|..|::..
Human   419 QNQ----VRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKET 479

  Fly   248 FF--GGFNVSRPVLSGSECYGNETELADCLHHDASQGIISC-HGNRQHVAAVICDYIAPDLVVDY 309
            :|  |.......|:||..|.|.|..|..|..|    |.:.| ||..:.:|.|.|...|||||::.
Human   480 WFWSGTPRAQEVVMSGVRCSGTELALQQCQRH----GPVHCSHGGGRFLAGVSCMDSAPDLVMNA 540

  Fly   310 LEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPF 374
            ..:::||:|||||:..:.||.||||::..|     |...|.|..||||:|:....|.|..||||.
Human   541 QLVQETAYLEDRPLSQLYCAHEENCLSKSA-----DHMDWPYGYRRLLRFSTQIYNLGRTDFRPK 600

  Fly   375 KEKSQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYGDQ 439
            ..:..|.||.||.|:||:|||..:|:..|.|.|||:||||||||||:||..|:.::|.|||:|:|
Human   601 TGRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACANFGEQ 665

  Fly   440 GISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTANFARVQ 504
            |:::.|.|.|.:::||||||:||:.||.|:.::.:||.::|||.::.||...|...|..:...:.
Human   666 GVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLH 730

  Fly   505 NCQLG 509
            ||..|
Human   731 NCHTG 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	35/99 (35%)
		SRCR	66..160	CDD:278931	33/93 (35%)
		SR	193..298	CDD:214555	47/110 (43%)
		SRCR	198..298	CDD:278931	43/105 (41%)
		Lysyl_oxidase	303..503	CDD:279521	92/199 (46%)
LOXL4	XP_005270273.1	SR	32..132	CDD:214555
		SR	174..286	CDD:214555
		SR	312..412	CDD:214555	36/117 (31%)
		SR	422..529	CDD:214555	47/110 (43%)
		Lysyl_oxidase	534..733	CDD:307371	93/203 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2492
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I2023
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	1	1.000	-	-		otm41693
orthoMCL	1	0.900	-	-		OOG6_104333
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X896
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830