DRSC/TRiP Functional Genomics Resources

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Protein Alignment Loxl2 and LOXL4

DIOPT Version :10

Sequence 1:NP_523806.2 Gene:Loxl2 / 37485 FlyBaseID:FBgn0034660 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_005270273.1 Gene:LOXL4 / 84171 HGNCID:17171 Length:757 Species:Homo sapiens


Alignment Length:460 Identity:182/460 - (39%)
Similarity:254/460 - (55%) Gaps:37/460 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 KEEGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGFFGPAR 120
            ::|..:||..|....||.:|||.|.:||.|||..|:...|.:|||||||...|........|...
Human   307 EQEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGARLGQGL 371

  Fly   121 RRFWMDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVCYPPENALIPMATPIIRDEDLPKYPI 185
            ....:..:.|.|:|:.|.||......:|.|:....|.|.|                  ::|....
Human   372 GPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRC------------------NVPNMGF 418

  Fly   186 HSRSRLYVRLRGGRSRIEGRVEVSLDGG---RWGSVCADGWSLLEANVVCRQLGLGYASEAFQTD 247
            .::    |||.|||...||.:||.::..   ||||||::.|.|.||.|.|||||||:|..|::..
Human   419 QNQ----VRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKET 479

  Fly   248 FF--GGFNVSRPVLSGSECYGNETELADCLHHDASQGIISC-HGNRQHVAAVICDYIAPDLVVDY 309
            :|  |.......|:||..|.|.|..|..|..|    |.:.| ||..:.:|.|.|...|||||::.
Human   480 WFWSGTPRAQEVVMSGVRCSGTELALQQCQRH----GPVHCSHGGGRFLAGVSCMDSAPDLVMNA 540

  Fly   310 LEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPF 374
            ..:::||:|||||:..:.||.||||::..|     |...|.|..||||:|:....|.|..||||.
Human   541 QLVQETAYLEDRPLSQLYCAHEENCLSKSA-----DHMDWPYGYRRLLRFSTQIYNLGRTDFRPK 600

  Fly   375 KEKSQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYGDQ 439
            ..:..|.||.||.|:||:|||..:|:..|.|.|||:||||||||||:||..|:.::|.|||:|:|
Human   601 TGRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACANFGEQ 665

  Fly   440 GISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTANFARVQ 504
            |:::.|.|.|.:::||||||:||:.||.|:.::.:||.::|||.::.||...|...|..:...:.
Human   666 GVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLH 730

  Fly   505 NCQLG 509
            ||..|
Human   731 NCHTG 735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Loxl2NP_523806.2 SR 61..161 CDD:214555 35/99 (35%)
SR 193..298 CDD:214555 47/110 (43%)
Lysyl_oxidase 303..506 CDD:460102 92/202 (46%)
LOXL4XP_005270273.1 SR 32..132 CDD:214555
SR 174..286 CDD:214555
SR 312..412 CDD:214555 36/117 (31%)
SR 422..529 CDD:214555 47/110 (43%)
Lysyl_oxidase 534..732 CDD:460102 92/202 (46%)
Blue background indicates that the domain is not in the aligned region.

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