DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and si:ch73-127m5.1

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_009305107.1	Gene:	si:ch73-127m5.1 / 799158	ZFINID:	ZDB-GENE-130531-25	Length:	835	Species:	Danio rerio

Alignment Length:	282	Identity:	107/282 - (37%)
Similarity:	133/282 - (47%)	Gaps:	52/282 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HMADAVVQHRSLEDARQERQRLVHRYTKVLNKEEGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDE 89
            ||.||.|.              .:.||      :|.:|||.|||.:||.:||.|:..||.||||.
Zfish   318 HMEDAGVS--------------CNPYT------DGVVRLVDGDNPWEGRLEVYHSRDWGTVCDDS 362

  Fly    90 WDSTEADIVCRQLGFPGMRRYTRSGFFGPARRRFWMDNLFCEGHEQELVDCHFEGWGENDCEPGE 154
            |....|.:|||||||.|......:|.||.......:|::.|||.|..|::|....||.:||...|
Zfish   363 WTEPHAQVVCRQLGFRGGAEVAPAGAFGEGTGLILLDDVECEGTESSLLECKHGVWGRHDCSHSE 427

  Fly   155 AAGVVCYPPENALIPMATPIIRDEDLPKYPIHSRSRLYVRLRGGRSRIEGRVEVSLDGGRWGSVC 219
            ..|:.|:..||..:|:|.             .|...| |||.||.||.||||||.|: |.|||||
Zfish   428 DVGIRCHRVENNEVPLAP-------------ESTGPL-VRLAGGDSRKEGRVEVFLN-GEWGSVC 477

  Fly   220 ADGWSLLEANVVCRQLGLGYASEAFQTDFFGGFNVSRPVLSGSECYGNETELADCLHHDASQGII 284
            ..||:.:.|.|||||||....|:|....:||. ......||...|.|.|:.|.:|
Zfish   478 DHGWNDVNAAVVCRQLGFNGESKARPMGYFGA-GKGTIHLSNVRCTGKESLLGEC---------- 531

  Fly   285 SCHGNRQHV------AAVICDY 300
            ...|...||      |.|:|||
Zfish   532 PSKGQDSHVCKHGQDAGVVCDY 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	43/99 (43%)
		SRCR	66..160	CDD:278931	40/93 (43%)
		SR	193..298	CDD:214555	46/110 (42%)
		SRCR	198..298	CDD:278931	42/105 (40%)
		Lysyl_oxidase	303..503	CDD:279521
si:ch73-127m5.1	XP_009305107.1	KR	49..112	CDD:294073
		SR	118..217	CDD:214555
		SRCR	123..218	CDD:278931
		SR	227..327	CDD:214555	5/22 (23%)
		SRCR	236..327	CDD:278931	5/22 (23%)
		SR	334..433	CDD:214555	43/98 (44%)
		SRCR	339..433	CDD:278931	40/93 (43%)
		SR	452..551	CDD:214555	46/110 (42%)
		SRCR	457..551	CDD:278931	42/105 (40%)
		Tryp_SPc	581..823	CDD:214473
		Tryp_SPc	582..826	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910