DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and lgals3bp.1

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_998038.1	Gene:	lgals3bp.1 / 405809	ZFINID:	ZDB-GENE-040426-2262	Length:	572	Species:	Danio rerio

Alignment Length:	281	Identity:	82/281 - (29%)
Similarity:	117/281 - (41%)	Gaps:	90/281 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQRLVHRYTKVLNKEEGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGM 107
            |:.|..|..:::  :||.:||||.... .|.:||.|:|:||.||||.||..||.:|||||||||.
Zfish    16 RRTLFDRPKQLM--QEGRVRLVGVIPS-SGRVEVYHDGQWGTVCDDGWDLAEAQVVCRQLGFPGA 77

  Fly   108 RRYTRSGFFGPARRRFWMDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVCYPPENALIPMAT 172
            ......|.:|....|.|:|::.|:|.|..|.:|.|:|||.:||...|.|||:|.|.:|      |
Zfish    78 VSVATGGQYGEGSGRVWLDDMNCKGSESLLSECSFKGWGVSDCTHKEDAGVICAPGKN------T 136

  Fly   173 PIIRDEDLPKYPIHSRSRLYVRLRGGRSRIEGRVEVSLDGGRWGSVCADGWSLLEANVVCRQLGL 237
            ..||                      :..::..:.:|.|                       |||
Zfish   137 TSIR----------------------QMSVDNSLGLSDD-----------------------LGL 156

  Fly   238 GYASEAFQTDFFGGFNVSRPVLSGSECYGNETELADCLHHDASQGIISCHGNRQHVAAVICDYIA 302
            .:.||       .|.:.:..|...||    |.||..|:|.                   :...|.
Zfish   157 LFDSE-------DGCDFTIAVRDLSE----EAELTFCVHR-------------------VILMIY 191

  Fly   303 PDLVVDY------LEIEQTAH 317
            |:|.:.:      ::|.||.|
Zfish   192 PELNLTHDTRNITVDISQTCH 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	48/99 (48%)
		SRCR	66..160	CDD:278931	44/93 (47%)
		SR	193..298	CDD:214555	16/104 (15%)
		SRCR	198..298	CDD:278931	16/99 (16%)
		Lysyl_oxidase	303..503	CDD:279521	6/21 (29%)
lgals3bp.1	NP_998038.1	SR	32..130	CDD:214555	48/98 (49%)
		SRCR	36..131	CDD:278931	45/95 (47%)
		BTB	165..255	CDD:197585	15/71 (21%)
		BACK	271..368	CDD:197943
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6174
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000