DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Loxl2 and Loxl3

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001101336.1	Gene:	Loxl3 / 312478	RGDID:	1311011	Length:	754	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	191/460 - (41%)
Similarity:	263/460 - (57%)	Gaps:	41/460 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 EGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGFFGPARRR 122
            |.::||.||.:..||.:|||..|.||.|||.:||...|.:|||:|||...|........|.....
  Rat   305 EASVRLKGGAHPGEGRVEVLKAGTWGTVCDRKWDLQAASVVCRELGFGTAREALSGARMGQGMGA 369

  Fly   123 FWMDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVCYPPENALIPMATPIIRDEDLPKYPIHS 187
            ..:..:.|.|.|..|..|..:.....||...:.|.|.|                  :||...:.:
  Rat   370 IHLSEVRCSGQEPSLWKCPSKNITAEDCSHSQDAAVRC------------------NLPYTGVET 416

  Fly   188 RSRLYVRLRGGRSRIEGRVEVSLDGG-----RWGSVCADGWSLLEANVVCRQLGLGYASEAFQ-T 246
            :    :||.|||||.||||||.:  |     |||.:|.|.|..|||.|.|||||||||:...| |
  Rat   417 K----IRLSGGRSRYEGRVEVQI--GVPGHLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQET 475

  Fly   247 DFFGGFNVSRPVLSGSECYGNETELADCLHHDASQGIISCH--GNRQHVAAVICDYIAPDLVVDY 309
            .::...||:..|:||..|.|:|..|..|.||:..   ::|.  |.| ..|.|||...|.||::..
  Rat   476 WYWDSGNVTEVVMSGVRCTGSELSLNQCAHHNTH---VTCKRTGTR-FTAGVICSETASDLLLHS 536

  Fly   310 LEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPF 374
            ..:::||::||||:.::.||.||||:|:.|     ...:|.|..||||:|::...|.|.|||||.
  Rat   537 ALVQETAYIEDRPLHMLYCAAEENCLASSA-----RSANWPYGHRRLLRFSSQIHNLGRADFRPK 596

  Fly   375 KEKSQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYGDQ 439
            ..:..|.||.||.|:|||::|..:||....|.|||:||||||||||:.|...|:|:|.|||:|:|
  Rat   597 AGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ 661

  Fly   440 GISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTANFARVQ 504
            ||::.|.|:|.:::||||:|:||:.||.|:|::.|||.|:|||.::.|||..|:..|..:...|.
  Rat   662 GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVH 726

  Fly   505 NCQLG 509
            ||.:|
  Rat   727 NCHIG 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	35/99 (35%)
		SRCR	66..160	CDD:278931	32/93 (34%)
		SR	193..298	CDD:214555	52/112 (46%)
		SRCR	198..298	CDD:278931	49/107 (46%)
		Lysyl_oxidase	303..503	CDD:279521	93/199 (47%)
Loxl3	NP_001101336.1	SR	46..145	CDD:214555
		SRCR	54..146	CDD:278931
		SR	170..282	CDD:214555
		SRCR	187..282	CDD:278931
		SR	308..408	CDD:214555	36/117 (31%)
		SRCR	313..408	CDD:278931	33/112 (29%)
		SR	418..526	CDD:214555	53/113 (47%)
		SRCR	423..526	CDD:278931	50/108 (46%)
		Lysyl_oxidase	531..725	CDD:279521	93/198 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2469
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	1	1.000	-	-		otm45818
orthoMCL	1	0.900	-	-		OOG6_104333
Panther	1	1.100	-	-	LDO	PTHR45817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X896
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970