DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Loxl2 and Loxl4

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001101062.1	Gene:	Loxl4 / 309380	RGDID:	1308588	Length:	758	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	193/482 - (40%)
Similarity:	264/482 - (54%)	Gaps:	49/482 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ERQRLVHRYTKVLNKEEGA-----IRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQ 101
            :||:     .|...||.||     :||..|....||.:|||.|.:||.|||..|:...|.:||||
  Rat   294 QRQK-----PKPKRKESGAEQELKVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQ 353

  Fly   102 LGFPGMRRYTRSGFFGPARRRFWMDNLFCEGHEQELVDC-HFEGWGENDCEPGEAAGVVCYPPEN 165
            |||...|........|.......:..:.|.|:||.:.|| ..|| .:|.|:....|.|.|
  Rat   354 LGFGSAREALFGAQLGQGLGPIHLSEVRCRGYEQTIGDCLALEG-SQNGCQHANDAAVRC----- 412

  Fly   166 ALIPMATPIIRDEDLPKYPIHSRSRLYVRLRGGRSRIEGRVEVSLDGG---RWGSVCADGWSLLE 227
                         ::|.....::    |||.|||:..||.|||.::..   |||:||:|.|.|.|
  Rat   413 -------------NIPDMGFQNK----VRLAGGRNSEEGVVEVQVEVNGVPRWGTVCSDHWGLTE 460

  Fly   228 ANVVCRQLGLGYASEAFQTDFF--GGFNVSRPVLSGSECYGNETELADCLHHDASQGIISC-HGN 289
            |.|.|||||||:|:.|.:..::  |.......|:||..|.|.|..|..|..|    |.:.| ||:
  Rat   461 AMVTCRQLGLGFANFAIKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQCQRH----GPVHCSHGS 521

  Fly   290 RQHVAAVICDYIAPDLVVDYLEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSR 354
            .:..|.|.|...|||||::...:::||:|||||:.::.||.||||::..|     |...|.|..|
  Rat   522 GRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENCLSKSA-----DHMDWPYGHR 581

  Fly   355 RLLKFTAAAINAGNADFRPFKEKSQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLE 419
            |||:|::...|.|.|||||...:..|.||.||.|:||:|||..:|:..|.|.|||:|||||||||
  Rat   582 RLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLE 646

  Fly   420 DSNCLPGVAKKYNCANYGDQGISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMN 484
            |:||..||.::|.|||:|:||:::.|.|.|.:::||||||:||:.||.|:.::.:||...|||.:
  Rat   647 DTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDCQWVDITDVSPGDYIFQVVVNPTNDVAESD 711

  Fly   485 YDNNAAICDLIYTANFARVQNCQLGRP 511
            :.||...|...|......:.||..|.|
  Rat   712 FSNNMIRCRCKYDGQRVWLHNCHTGDP 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	37/100 (37%)
		SRCR	66..160	CDD:278931	35/94 (37%)
		SR	193..298	CDD:214555	47/110 (43%)
		SRCR	198..298	CDD:278931	43/105 (41%)
		Lysyl_oxidase	303..503	CDD:279521	94/199 (47%)
Loxl4	NP_001101062.1	SR	33..133	CDD:214555
		SRCR	42..133	CDD:278931
		SR	175..287	CDD:214555
		SRCR	177..287	CDD:278931
		SR	313..413	CDD:214555	38/118 (32%)
		SRCR	318..413	CDD:278931	36/113 (32%)
		SR	447..530	CDD:214555	36/86 (42%)
		SRCR	447..530	CDD:278931	36/86 (42%)
		Lysyl_oxidase	535..730	CDD:279521	94/199 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2469
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	1	1.000	-	-		otm45818
orthoMCL	1	0.900	-	-		OOG6_104333
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X896
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830