DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Loxl2 and Loxl2

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038949076.1	Gene:	Loxl2 / 290350	RGDID:	1308435	Length:	823	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	198/507 - (39%)
Similarity:	273/507 - (53%)	Gaps:	83/507 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RYTKVLNKEEG-------AIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGF-- 104
            |:.|....|:.       .:||.||....||.:|||.||:||.||||:||...|.:|||:|||
  Rat   329 RFRKAYKPEQDHVSLQQPLVRLRGGAQVGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGT 393

  Fly   105 -----PGMR-------RYTR--------------SGF----FGPARRRFWMDNLFCEGHEQELVD 139
                 .|.|       .||.              ||.    .||..    ::.:.|.|.|:.::|
  Rat   394 AKEAVTGSRLGQGIGWEYTEGKHGIPALLLGKASSGSECTGIGPIH----LNEVQCTGTEKSIID 454

  Fly   140 C--HFEGWGENDCEPGEAAGVVCYPPENALIPMATPIIRDEDLPKYPIHSRSRLYVRLRGGRSRI 202
            |  :.|..|   |...|.|||.|                  ::|......:    |||.|||:..
  Rat   455 CKLNTESQG---CNHEEDAGVRC------------------NIPIMGFQKK----VRLNGGRNPY 494

  Fly   203 EGRVEVSLDGGR---WGSVCADGWSLLEANVVCRQLGLGYASEAFQTDFF--GGFNVSRPVLSGS 262
            ||||||..:...   ||:||...|.::||.|||||||||:||.|||..::  |....::.::||.
  Rat   495 EGRVEVLTERNGSLVWGNVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGNIFANKVIMSGV 559

  Fly   263 ECYGNETELADCLHHDASQGIISCHGNRQHVAAVICDYIAPDLVVDYLEIEQTAHLEDRPMLLMQ 327
            :|.|.|..||.|.|   .:.::...|..|:.|.|.|...|||||::...::|||:||||||.|:|
  Rat   560 KCSGTELSLAHCRH---DEEVVCPEGGVQYGAGVACSETAPDLVLNAEIVQQTAYLEDRPMALLQ 621

  Fly   328 CAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPFKEKSQWEWHMCHMHFHSM 392
            |||||||::..|........|     ||||:|::...|.|.:||||...:..|.||.||.|:|||
  Rat   622 CAMEENCLSASAVHTDPTRGH-----RRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSM 681

  Fly   393 EVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYGDQGISINCSDVYLYNLDCQW 457
            |||..:|:.:|.|.|||:||||||||||:.|...:.|.|.|||:|:|||::.|.|:|.:::||||
  Rat   682 EVFTYYDLLSLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQW 746

  Fly   458 VDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTANFARVQNCQLG 509
            :|:||:.||.|:.::.|||.::|.|.::.||...|...|......:.||.:|
  Rat   747 IDITDVPPGDYLFQVVINPNYEVPESDFSNNIMKCRSRYDGYRIWMYNCHVG 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	46/133 (35%)
		SRCR	66..160	CDD:278931	43/127 (34%)
		SR	193..298	CDD:214555	47/109 (43%)
		SRCR	198..298	CDD:278931	43/104 (41%)
		Lysyl_oxidase	303..503	CDD:279521	95/199 (48%)
Loxl2	XP_038949076.1	SR	73..174	CDD:214555
		SR	216..316	CDD:214555
		SR	348..475	CDD:214555	45/160 (28%)
		SR	485..593	CDD:214555	45/112 (40%)
		Lysyl_oxidase	598..797	CDD:395944	91/192 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2469
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1742
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	1	1.000	-	-		otm45818
orthoMCL	1	0.900	-	-		OOG6_104333
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X896
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830