DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and Lox

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_058757.1	Gene:	Lox / 24914	RGDID:	3015	Length:	411	Species:	Rattus norvegicus

Alignment Length:	210	Identity:	85/210 - (40%)
Similarity:	129/210 - (61%)	Gaps:	6/210 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 YIAPDLVVDYLEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAI 364
            |..||||.|...|:.:.:::...|..::||.||||:|:.||:....|    |..|.||:|.....
  Rat   204 YGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRD----YDHRVLLRFPQRVK 264

  Fly   365 NAGNADFRPFKEKSQWEWHMCHMHFHSMEVFATFDIFNL-RGIKVAQGHKASFCLEDSNCLPGVA 428
            |.|.:||.|.:.:..||||.||.|:|||:.|:.:|:.:. ...:||:||||||||||::|..|..
  Rat   265 NQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYH 329

  Fly   429 KKYNCANYGDQGISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICD 493
            :::.|..: .||:|..|.|.|..::||||:|:||:.||.|:||:::||.:.|.|.:|.||...|:
  Rat   330 RRFACTAH-TQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCE 393

  Fly   494 LIYTANFARVQNCQL 508
            :.||.:.|....|.:
  Rat   394 IRYTGHHAYASGCTI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555
		SRCR	66..160	CDD:278931
		SR	193..298	CDD:214555
		SRCR	198..298	CDD:278931
		Lysyl_oxidase	303..503	CDD:279521	83/200 (42%)
Lox	NP_058757.1	PRK12323	<56..>155	CDD:237057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..168
		Lysyl-oxidase like	207..411		84/207 (41%)
		Lysyl_oxidase	207..408	CDD:366506	84/205 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020