DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and DMBT1

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001364459.1	Gene:	DMBT1 / 1755	HGNCID:	2926	Length:	2542	Species:	Homo sapiens

Alignment Length:	248	Identity:	100/248 - (40%)
Similarity:	131/248 - (52%)	Gaps:	16/248 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGFFGPARRRFW 124
            |:|||.||...:|.:|:|:.|.||.||||.||:.:|::||||||.........:.:||.......
Human   101 ALRLVNGDGRCQGRVEILYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIA 165

  Fly   125 MDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVC--YPPENALIPMATPIIRDEDLPKYPIH- 186
            :|::.|.|||..|..|...||..::|..||.|||:|  ..|::.|.|.:.|:   ...|..|..
Human   166 LDDVRCSGHESYLWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPV---RISPPVPTEG 227

  Fly   187 SRSRLYVRLRGGRSRIEGRVEVSLDGGRWGSVCADGWSLLEANVVCRQLGLGYASEAFQTDFFGG 251
            |.|.|.:||..|..|..||||| |..|.||:||.|.|...:|||||||||.|:|..|.....||
Human   228 SESSLALRLVNGGDRCRGRVEV-LYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFG- 290

  Fly   252 FNVSRP-VLSGSECYGNETELADCLHHDASQGIISCHGNRQHVAAVICDYIAP 303
             ..|.| ||....|.|:|:.|..|.|:    |.::.:......|.|||.  ||
Human   291 -QGSGPIVLDDVRCSGHESYLWSCPHN----GWLTHNCGHSEDAGVICS--AP 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	42/101 (42%)
		SRCR	66..160	CDD:278931	38/93 (41%)
		SR	193..298	CDD:214555	44/105 (42%)
		SRCR	198..298	CDD:278931	42/100 (42%)
		Lysyl_oxidase	303..503	CDD:279521	1/1 (100%)
DMBT1	NP_001364459.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..356		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..855
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1093..1114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1222..1243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1372
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1501
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6689
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910