DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and Loxl1

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_034859.2	Gene:	Loxl1 / 16949	MGIID:	106096	Length:	607	Species:	Mus musculus

Alignment Length:	207	Identity:	86/207 - (41%)
Similarity:	129/207 - (62%)	Gaps:	6/207 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 PDLVVDYLEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAG 367
            ||||.|...::.:.:::...:..::||.||.|:|:.||..:..|    |..|.||:|.....|.|
Mouse   403 PDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATD----YDLRVLLRFPQRVKNQG 463

  Fly   368 NADFRPFKEKSQWEWHMCHMHFHSMEVFATFDIFNL-RGIKVAQGHKASFCLEDSNCLPGVAKKY 431
            .|||.|.:.:..||||.||.|:|||:.|:.:|:.:. .|.|||:|||||||||||.|..|..|:|
Mouse   464 TADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDASTGKKVAEGHKASFCLEDSTCDFGNLKRY 528

  Fly   432 NCANYGDQGISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIY 496
            .|.:: .||:|..|.|.|..::||||:|:||:.||.|:||:.:||::.|.|.::.||...|::.|
Mouse   529 ACTSH-TQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHY 592

  Fly   497 TANFARVQNCQL 508
            |..:....||::
Mouse   593 TGRYVSTTNCKI 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555
		SRCR	66..160	CDD:278931
		SR	193..298	CDD:214555
		SRCR	198..298	CDD:278931
		Lysyl_oxidase	303..503	CDD:279521	84/200 (42%)
Loxl1	NP_034859.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..388
		Lysyl-oxidase like	403..607		86/207 (42%)
		Lysyl_oxidase	403..597	CDD:279521	84/198 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020