DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl2 and LOC100911413

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038957165.1	Gene:	LOC100911413 / 100911413	RGDID:	6493252	Length:	1961	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	128/465 - (27%)
Similarity:	183/465 - (39%)	Gaps:	92/465 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGFFGPARRRFW 124
            |:|||.|.:...|.:|:.:.|.||.||||.||..:|::||||||..|......|..||.......
  Rat   516 AVRLVNGGDRCRGRVEIFYQGSWGTVCDDSWDINDANVVCRQLGCGGALSAPGSDQFGQGSGSIV 580

  Fly   125 MDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVCYPPENALIPMATPIIRDEDLPKYPIHSRS 189
            :|.:.|.|:|..|.:|...||..::|:..|.|||:|...::.|.
  Rat   581 LDEVACTGNETYLWNCSHRGWLSHNCDHQEDAGVICSGTDSVLA--------------------- 624

  Fly   190 RLYVRLRGGRSRIEGRVEVSLDGGRWGSVCADGWSLLEANVVCRQLGLGYASEAFQTDFFGGFNV 254
               |||..|.:...||||: |..|.||:||.|.|.:.:|||||||||.|.|..|..:|.||..:.
  Rat   625 ---VRLVNGGNSCRGRVEI-LYQGSWGTVCDDSWDINDANVVCRQLGCGGALSAPGSDQFGQGSG 685

  Fly   255 SRPVLSGSECYGNETELADCLHHDASQGIISCHGNRQHVAAVICDYIAPDLVVDYLEIEQTAHLE 319
            | .||....|.||||.|.:|.|    :|.:|.:.:.|..|.|||......|.|..:....|.  .
  Rat   686 S-IVLDEVACTGNETYLWNCSH----RGWLSHNCDHQEDAGVICSGTDSGLAVRLVNGGDTC--R 743

  Fly   320 DRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPFKEKSQWEWHM 384
            .|..:|.|.:....|           |..|......::   ...:..|.|...|..:
  Rat   744 GRVEILYQGSWGTVC-----------DDSWDINDANVV---CRQLGCGGALSAPGSD-------- 786

  Fly   385 CHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYG----------DQ 439
                                  :..|| ..|..|::.:|....|..:||.:.|          |.
  Rat   787 ----------------------QFGQG-SGSIVLDEVSCTGHEAYLWNCTHRGWLSHNCGHQEDA 828

  Fly   440 GISINCSDVYLYNLDCQW-----VDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTAN 499
            |:..:.|.......|..:     .|.||.:....::........:|..:...:...:||..:..|
  Rat   829 GVICSASQTSSPTPDVSYRTELPTDGTDSVLAVRLVNGGDRCRGRVEILYQGSWGTVCDDSWDIN 893

  Fly   500 FARVQNCQLG 509
            .|:|...|||
  Rat   894 DAKVVCRQLG 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	39/99 (39%)
		SRCR	66..160	CDD:278931	36/93 (39%)
		SR	193..298	CDD:214555	47/104 (45%)
		SRCR	198..298	CDD:278931	44/99 (44%)
		Lysyl_oxidase	303..503	CDD:279521	33/214 (15%)
LOC100911413	XP_038957165.1	SR	81..181	CDD:214555
		SR	189..289	CDD:214555
		SR	317..417	CDD:214555
		SR	517..617	CDD:214555	39/99 (39%)
		SR	625..725	CDD:214555	48/105 (46%)
		SR	733..833	CDD:214555	22/146 (15%)
		SR	861..961	CDD:214555	9/43 (21%)
		SR	978..1078	CDD:214555
		CUB	1271..1379	CDD:238001
		SR	1394..1494	CDD:214555
		CUB	1509..1617	CDD:238001
		ZP	1628..1875	CDD:214579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000