DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Loxl2 and loxl4

DIOPT Version :9

Sequence 1:	NP_523806.2	Gene:	Loxl2 / 37485	FlyBaseID:	FBgn0034660	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_002664258.3	Gene:	loxl4 / 100320658	ZFINID:	ZDB-GENE-080722-19	Length:	810	Species:	Danio rerio

Alignment Length:	461	Identity:	181/461 - (39%)
Similarity:	260/461 - (56%)	Gaps:	47/461 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGFFGPARRRFW 124
            ::||..|....||.:|||..||||.|.|..||...|.:|||:|||...:......:.|.......
Zfish   364 SVRLKAGPRLGEGRVEVLREGKWGTVVDHLWDRISASVVCRELGFGTAKEALTGAYMGQGTGPIH 428

  Fly   125 MDNLFCEGHEQELVDCHFEGWGENDCEP-----GEAAGVVCYPPENALIPMATPIIRDEDLPKYP 184
            |:::.|.|.|:.::||.|:     |.:|     ...|.|.||                  :||..
Zfish   429 MNSVRCAGTERSILDCFFQ-----DVQPWTFKHNRDASVKCY------------------VPKTG 470

  Fly   185 IHSRSRLYVRLRGGRSRIEGRVEVSL-DGGR--WGSVCADGWSLLEANVVCRQLGLGYASEAFQT 246
            :.:.    |||.|||...||||||.: ||||  ||::|::.|.:.||.|||||||.|:|:.|.|.
Zfish   471 VENT----VRLAGGRDPAEGRVEVLMEDGGRKHWGTICSENWGINEAMVVCRQLGFGFAARAHQE 531

  Fly   247 DFF--GGFNVSRPVLSGSECYGNETELADCLHHDASQGIISC-HGNRQHVAAVICDYIAPDLVVD 308
            .::  |.......||||:.|.|.|..:..|..:    ..:.| .|.....|.|.|...|||||:|
Zfish   532 TYYWQGDPAAEEVVLSGAHCVGTEMSIQQCRRN----SYVHCPRGGGAKAAGVTCSETAPDLVLD 592

  Fly   309 YLEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRP 373
            ...::::::|||||:.|:.||.||||:::.|.::|     |.|..||||:|::..:|.|.|||||
Zfish   593 AQLVQESSYLEDRPLHLLTCAHEENCLSSSASRMQ-----WPYGHRRLLRFSSRIMNLGRADFRP 652

  Fly   374 FKEKSQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYGD 438
            ...:..|.||.||.|:||:|||..:|:..|.|.:||:||||||||||:.|..|:.|:::|.||||
Zfish   653 RASRESWTWHQCHRHYHSIEVFTHYDLLTLNGSRVAEGHKASFCLEDTYCPEGLHKRFSCYNYGD 717

  Fly   439 QGISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTANFARV 503
            ||||:.|.|.|.:::||||:|:||:.||.|::::.:||...:||.::.||...|...|..:...:
Zfish   718 QGISVGCWDTYRHDIDCQWIDITDVRPGDYIMQVEVNPSLDMAESDFMNNVMRCRCKYDGHRVFM 782

  Fly   504 QNCQLG 509
            ..|..|
Zfish   783 YGCHAG 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl2	NP_523806.2	SR	61..161	CDD:214555	35/104 (34%)
		SRCR	66..160	CDD:278931	33/98 (34%)
		SR	193..298	CDD:214555	46/110 (42%)
		SRCR	198..298	CDD:278931	42/105 (40%)
		Lysyl_oxidase	303..503	CDD:279521	92/199 (46%)
loxl4	XP_002664258.3	SR	37..138	CDD:214555
		SRCR	43..138	CDD:278931
		SR	233..341	CDD:214555
		SRCR	233..341	CDD:278931
		SR	365..465	CDD:214555	35/104 (34%)
		SRCR	370..464	CDD:278931	33/98 (34%)
		SR	475..583	CDD:214555	46/111 (41%)
		SRCR	480..583	CDD:278931	42/106 (40%)
		Lysyl_oxidase	587..780	CDD:279521	92/197 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2401
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1964
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	1	1.000	-	-		otm25165
orthoMCL	1	0.900	-	-		OOG6_104333
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X896
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.830