DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4021 and Khdrbs1

DIOPT Version :9

Sequence 1:	NP_611610.2	Gene:	CG4021 / 37484	FlyBaseID:	FBgn0034659	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_035447.3	Gene:	Khdrbs1 / 20218	MGIID:	893579	Length:	443	Species:	Mus musculus

Alignment Length:	319	Identity:	95/319 - (29%)
Similarity:	156/319 - (48%)	Gaps:	69/319 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSEITEEQPTTTHEYQPRLNEIAQKFLADLDEERQRLSAEFPLCALLIDEARDRVY-ATGRIPGK 70
            |:.:.....|...:.:|.     .|:|.:|..|:..|...|.....|:....:::. ...:...:
Mouse    83 PTPLLPPSATAAVKMEPE-----NKYLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDE 142

  Fly    71 ELYADVYRQKPMKIIQKVFVPVNQYPKFNFAGKILGPKGNSLRRLQEETQCKIALKGRSSMRDRN 135
            |.|.|::..|.||:.::|.:||.|||||||.||||||:||:::||||||..||::.|:.||||:.
Mouse   143 ENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKA 207

  Fly   136 KEEELR--SDPRYAHLQKNLFLEVSTVAIPAECHSRIAYALAEIRKYLIPDNNDEVSHEQLRELM 198
            ||||||  .||:||||..:|.:.:.....|.|.::.:|:|:.|::|:|:||..|::..||..||.
Mouse   208 KEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELS 272

  Fly   199 EID--PESAKNFKGLNLEAY------------RSVRDSNGASKYINLIK---------------- 233
            .::  ||.::. :|:::...            |.|....||     |::
Mouse   273 YLNGVPEPSRG-RGVSVRGRGAAPPPPPVPRGRGVGPPRGA-----LVRGTPVRGSITRGATVTR 331

  Fly   234 --------RVAENP-SKVADMEQV------------DYDYDEHHMPPIHLPTGYE--YS 269
                    |.|..| ::.|.::::            ||.||:.:....:  .|||  ||
Mouse   332 GVPPPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDTYAEQSY--EGYEGYYS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4021	NP_611610.2	SF1_like-KH	86..202	CDD:239088	58/119 (49%)
Khdrbs1	NP_035447.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		2/10 (20%)
		Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q07666	100..260		66/164 (40%)
		Qua1	103..153	CDD:318503	9/49 (18%)
		SF1_like-KH	157..276	CDD:239088	58/118 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..317		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		2/18 (11%)
		Interaction with HNRNPA1. /evidence=ECO:0000250\|UniProtKB:Q07666	351..443		9/40 (23%)
		Sam68-YY	366..415	CDD:318716	9/25 (36%)
		Interaction with ZBTB7A. /evidence=ECO:0000250\|UniProtKB:Q07666	400..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845527
Domainoid	1	1.000	56	1.000	Domainoid score	I10944
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D428083at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8696
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.860