DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4021 and KHDRBS1

DIOPT Version :9

Sequence 1:	NP_611610.2	Gene:	CG4021 / 37484	FlyBaseID:	FBgn0034659	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_006550.1	Gene:	KHDRBS1 / 10657	HGNCID:	18116	Length:	443	Species:	Homo sapiens

Alignment Length:	205	Identity:	76/205 - (37%)
Similarity:	123/205 - (60%)	Gaps:	10/205 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSEITEEQPTTTHEYQPRLNEIAQKFLADLDEERQRLSAEFPLCALLIDEARDRVY-ATGRIPGK 70
            |:.:.....|.:.:.:|.     .|:|.:|..|:..|...|.....|:....:::. ...:...:
Human    83 PTPLLPPSATASVKMEPE-----NKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDE 142

  Fly    71 ELYADVYRQKPMKIIQKVFVPVNQYPKFNFAGKILGPKGNSLRRLQEETQCKIALKGRSSMRDRN 135
            |.|.|::..|.||:.::|.:||.|||||||.||||||:||:::||||||..||::.|:.||||:.
Human   143 ENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKA 207

  Fly   136 KEEELR--SDPRYAHLQKNLFLEVSTVAIPAECHSRIAYALAEIRKYLIPDNNDEVSHEQLRELM 198
            ||||||  .||:||||..:|.:.:.....|.|.::.:|:|:.|::|:|:||..|::..||..||.
Human   208 KEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELS 272

  Fly   199 EID--PESAK 206
            .::  ||.::
Human   273 YLNGVPEPSR 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4021	NP_611610.2	SF1_like-KH	86..202	CDD:239088	58/119 (49%)
KHDRBS1	NP_006550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		2/12 (17%)
		Involved in homodimerization. /evidence=ECO:0000305\|PubMed:26758068	100..260		66/164 (40%)
		Qua1	102..153	CDD:406639	10/50 (20%)
		KH-I_KHDRBS1	152..257	CDD:411896	54/104 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..316		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346
		Interaction with HNRNPA1. /evidence=ECO:0000269\|PubMed:17371836	351..443
		Sam68-YY	366..415	CDD:406871
		Interaction with ZBTB7A. /evidence=ECO:0000269\|PubMed:24514149	400..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D428083at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810