Protein Alignment LBR and TM7SF2

DIOPT Version :9

• Sequence 1: NP_726114.1
• Gene: LBR / 37482
• FlyBaseID: FBgn0034657
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_003264.2
• Gene: TM7SF2 / 7108
• HGNCID: 11863
• Length: 418
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 126/462 - (27%)
• Similarity: 200/462 - (43%)
• Gaps: 74/462 - (16%)

  Fly   303 KAPREFGGWLGAFLFLLLLPTAVYYLTWSCTARNACQFKHLNLGIL--------LDVNYLTRQVF 359
            :||.||||.|||...|||||..:::|..:..:..|        .:|        |:|      ::
Human     8 RAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPA--------RLLGPPASLPGLEV------LW 58

  Fly   360 QPRVVGAFAAY---QVVVFLLVALLPGRRV-------HLTRETYKFNCL-AVSLT-LLIASGVAE 412
            .||.:..:.|:   |..::    |||.|:|       ..:|..|..|.. |:.|| ||:..|::.
Human    59 SPRALLLWLAWLGLQAALY----LLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSA 119

  Fly   413 YLKYPVVTFVLRHYLRFCIFGLVGAFVAAAWSYWLVDTAKYNVLRQTLTNDYGRTGSFVVDFALG 477
            .|....:..:|   |.......:.||:.:.:.|.....|..:.|...     |.:|:.:.||.||
Human   120 GLPLGALPEML---LPLAFVATLTAFIFSLFLYMKAQVAPVSALAPG-----GNSGNPIYDFFLG 176

  Fly   478 RQLNPKWLGRVDWKQFQYRLSLVTTLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYD 542
            |:|||    |:.:..|:|...|...||   .::...|....|.  .|..|....|.:..|...
Human   177 RELNP----RICFFDFKYFCELRPGLI---GWVLINLALLMKE--AELRGSPSLAMWLVNGFQ-- 230

  Fly   543 PATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYFYEQRVPI 606
                      |.||.||:..|..:.::.::.|:|:|.:|.. ..|..|:..:...::......|:
Human   231 ----------LLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPL 285

  Fly   607 SCWYAPLA--VAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVR 669
            .   .|:|  :..:.:.|..:.|.:.:.|..:|.|...|..|.:|||.|..|.:||:||.||.||
Human   286 G---LPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVR 347

  Fly   670 QPNYLGDIVALLALAAPMALRPAWPPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRS 734
            .||||||::..||.:.|..:.... |...|.....||:||..|...:...:|..:||.|..:|..
Human   348 HPNYLGDLIMALAWSLPCGVSHLL-PYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPY 411

  Fly   735 YILPRVY 741
            .|:|.:|
Human   412 RIMPYIY 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	PEMT	304..741	CDD:304400	125/459 (27%)
TM7SF2	NP_003264.2	PEMT	73..418	CDD:389781	103/381 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7481
eggNOG	1	0.900	-	-		E1_KOG1435
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4664
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53801
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102075
Panther	1	1.100	-	-	LDO	PTHR21257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3179
SonicParanoid	1	1.000	-	-		X598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860