DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LBR and Dhcr7

DIOPT Version :9

Sequence 1:	NP_726114.1	Gene:	LBR / 37482	FlyBaseID:	FBgn0034657	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_071784.1	Gene:	Dhcr7 / 64191	RGDID:	621769	Length:	471	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	123/506 - (24%)
Similarity:	189/506 - (37%)	Gaps:	142/506 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 W--LGAFLFLLLL-PTAVYYLTWSCTARNACQFKHLNLGI------LLDVNYLTRQVF--QPRVV 364
            |  |.:.:||||. |..|||...:|. :.:|......|.:      |.|:...|..|.  ..::.
  Rat    33 WFSLVSVIFLLLFAPFIVYYFIMACD-QYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLY 96

  Fly   365 GAFAAYQVVVFLLV-----ALLPGRRVHLTRETYKFNCLAVSLTLLIASGVAEYLKYPV---VTF 421
            ..:.::||:::..:     ..|||         |.......::|   .:|:..  ||.|   ..:
  Rat    97 ALWVSFQVLLYSWLPDFCHRFLPG---------YVGGVQEGAIT---PAGIVN--KYEVNGLQAW 147

  Fly   422 VLRHYLRFCIFGLVGAFVAAAWS-----------YWLVDTAKYNV---------LRQTLTNDYGR 466
            ::.|:|.|     |.|::.:.:|           .|..:...|.|         |..|...|...
  Rat   148 LITHFLWF-----VNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKF 207

  Fly   467 TGSFVVDFALGRQLNP---KWLGRVDWKQ-FQYRLSLVT-TLIYATCYIYQTLVWPQKPQLGEQE 526
            ||:|..::.:|.:.||   ||.   |:|. |..|..:|. |||        .|.:..|.|  |..
  Rat   208 TGNFFYNYMMGIEFNPRIGKWF---DFKLFFNGRPGIVAWTLI--------NLSFAAKQQ--ELY 259

  Fly   527 GYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYG-------CLLLLR 584
            |::..:....|.:.            ..||||....|.....:.::.|:.:|       |:.|
  Rat   260 GHVTNSMILVNVLQ------------AIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL-- 310

  Fly   585 YAATPYLLTAVTKYFYEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRL-NSQSPIFAN- 647
                |||.|....|.....|.:|   .|.|:..|| |||:      .| |.:|: |.|..:|..
  Rat   311 ----PYLYTLQGLYLVYHPVQLS---TPNALGVLL-LGLV------GY-YIFRMTNHQKDLFRRT 360

  Fly   648 -------------IETIHT-----YQGSRLLLSGMWGWVRQPNYLGDIVALLALAAPMA----LR 690
                         ||..:|     ...|:||:||.||..|..||.||::..||......    |
  Rat   361 DGHCLIWGKKPKAIECSYTSADGLKHRSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLL- 424

  Fly   691 PAWPPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRSYILPRVY 741
                |...:..:.:||.||..|...|...:|...|:||...|...:||.::
  Rat   425 ----PYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYVAAVPYRLLPGIF 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	PEMT	304..741	CDD:304400	123/504 (24%)
Dhcr7	NP_071784.1	PEMT	89..471	CDD:419701	106/447 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354156
Domainoid	1	1.000	99	1.000	Domainoid score	I6883
eggNOG	1	0.900	-	-		E1_KOG1435
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4518
OMA	1	1.010	-	-		QHG53801
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.800