DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LBR and erg24

DIOPT Version :9

Sequence 1:	NP_726114.1	Gene:	LBR / 37482	FlyBaseID:	FBgn0034657	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_596767.1	Gene:	erg24 / 2540113	PomBaseID:	SPBC16G5.18	Length:	424	Species:	Schizosaccharomyces pombe

Alignment Length:	482	Identity:	113/482 - (23%)
Similarity:	199/482 - (41%)	Gaps:	94/482 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 AEISCRQLKAPREFGGWLGAFLFLLLLPTAVYYLTWSCTARNACQFKHLNLGILLDVNYLTRQVF 359
            |:.:.::.|...||.|.:|| |.:.:|.|.|.:.::.......|..|...:.          .:|
pombe     2 AKGAVKKEKFEYEFFGPIGA-LGVTVLTTVVSFGSFYICNEEGCPAKFSKIS----------HIF 55

  Fly   360 QPRVVGAFAAYQVVVFLL----VALL---------PGRRV--HLTRETYKFN-----CL-----A 399
            :...:  |....::::||    :.||         .|..:  ..||..||.|     ||     .
pombe    56 KKTPL--FDQKSLILYLLWFSTLTLLWKCTNGKWAKGTPIDDKGTRLLYKINGFNSACLILGVVC 118

  Fly   400 VSLTLLIASGVAEYLKYPVVTFVLRHYLRFCIFGLVGAFVAAAWSYWLVDTAKYNVLRQTLTNDY 464
            .|:.||.||         .:.|:..::|:......|.:.|...:.|......|..:.:.
pombe   119 TSIYLLGAS---------CMEFIWDNFLQLMFAAYVFSVVLCTFCYVQSFFGKQQLAKG------ 168

  Fly   465 GRTGSFVVDFALGRQLNPKWLGRVDWKQF-QYRLSLVTTLIYATCY-IYQTLVWPQKPQLGEQEG 527
            |.:|:.:.|:.:||.|||: :|..|.|.| :.|..|:..:::...: .:|.||      ||.:
pombe   169 GTSGNILFDWFIGRSLNPR-IGNFDIKCFCELRPGLILWVVFDIAFACHQYLV------LGGR-- 224

  Fly   528 YLYQAKYYWNNVNYDPATLFSASCLL------FYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RY 585
                               .:.|.:|      :||||::|.|..:.::.::..:|:|.:|.. ..
pombe   225 -------------------ITDSMVLVIIFHTWYVLDSLINESAVLTTMDITTDGFGYMLSFGDL 270

  Fly   586 AATPYLLTAVTKYFYEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIET 650
            ...|:|.:...:|.....|.:.. ...||:..|..||..:.|.:...|.::|.|...|...:::.
pombe   271 VWVPFLYSLQARYLAFHPVDLGL-VKTLAILCLQFLGYYIFRGANGQKNRFRSNPNDPKLKHLKF 334

  Fly   651 IHTYQGSRLLLSGMWGWVRQPNYLGDIVALLALAAPMAL-RPAWPPVLGLSLIILLLLHRATRAN 714
            |.|.:|::||.||.||..|..||.||.:...|...|... .|.  |...::...:||:||..|.:
pombe   335 IQTKRGTKLLTSGWWGMARHINYFGDWIMAWAWCLPAGFGSPI--PYFYVAYFGVLLVHRNARDD 397

  Fly   715 ARNQARYHSSWQRYSTQVRSYILPRVY 741
            .:.:.:|...|::|...|:..|:|.||
pombe   398 HKCRVKYGEDWEKYCKAVKYRIIPYVY 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	PEMT	304..741	CDD:304400	109/471 (23%)
erg24	NP_596767.1	PEMT	12..424	CDD:304400	109/470 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2251
eggNOG	1	0.900	-	-		E1_KOG1435
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2455
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53801
OrthoFinder	1	1.000	-	-		FOG0000851
OrthoInspector	1	1.000	-	-		oto102047
orthoMCL	1	0.900	-	-		OOG6_102075
Panther	1	1.100	-	-	O	PTHR21257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3179
SonicParanoid	1	1.000	-	-		X598
TreeFam	1	0.960	-	-
	13	12.810