Protein Alignment LBR and DHCR7

DIOPT Version :10

• Sequence 1: NP_726114.1
• Gene: LBR / 37482
• FlyBaseID: FBgn0034657
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001412036.1
• Gene: DHCR7 / 1717
• HGNCID: 2860
• Length: 492
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 120/527 - (22%)
• Similarity: 187/527 - (35%)
• Gaps: 167/527 - (31%)

  Fly   311 W--LGAFLFLLLL-PTAVYYLTWSCTARNACQFKHLNLGILLDV--------------NYLTRQV 358
            |  |.:.:||||. |..|||...:|.     |:.....|.::|:              ..:||:.
Human    37 WFSLASVIFLLLFAPFIVYYFIMACD-----QYSCALTGPVVDIVTGHARLSDIWAKTPPITRKA 96

  Fly   359 FQPRVVGAFAAYQVVVFLLV-----ALLPGRRVHLTR---------ETYKFNCL-AVSLTLLIAS 408
            .|  :...:..:||:::..:     ..|||....:..         ..|:.|.| |..||.|:..
Human    97 AQ--LYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWF 159

  Fly   409 GVAEYLKYPVVTFVLRHY--LRFC--IFGLVGAFVAAAWSY---------------WLVDTAKYN 454
            ..|..|.:...|.:..::  |.:|  |.|...:..|....|               |||..
Human   160 ANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCFPGEPCWLVPI---- 220

  Fly   455 VLRQTLTNDYGRTGSFVVDFALGRQLNP---KWLGRVDWKQ-FQYRLSLVT-TLIYAT------- 507
                .:......||:|..::.:|.:.||   ||.   |:|. |..|..:|. |||..:
Human   221 ----PMAGQCKFTGNFFYNYMMGIEFNPRIGKWF---DFKLFFNGRPGIVAWTLINLSFAAKQRE 278

  Fly   508 --CYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSF 570
              .::...:|.....|.      :|...::||...|                         ..:.
Human   279 LHSHVTNAMVLVNVLQA------IYVIDFFWNETWY-------------------------LKTI 312

  Fly   571 ELQHEGYG-------CLLLLRYAATPYLLTAVTKYFYEQRVPISCWYAPLAVAALLSLGLLVKRF 628
            ::.|:.:|       |:.|      |||.|....|.....|.:|   .|.||..|| |||:
Human   313 DICHDHFGWYLGWGDCVWL------PYLYTLQGLYLVYHPVQLS---TPHAVGVLL-LGLV---- 363

  Fly   629 SCAYKYKYRL-NSQSPIFAN--------------IETIHT-----YQGSRLLLSGMWGWVRQPNY 673
              .| |.:|: |.|..:|..              ||..:|     ...|:||:||.||..|..||
Human   364 --GY-YIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNY 425

  Fly   674 LGDIVALLALAAPMA----LRPAWPPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRS 734
            :||::..||......    |     |...:..:.:||.||..|...|..::|...|:||:..|..
Human   426 VGDLMGSLAYCLACGGGHLL-----PYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPY 485

  Fly   735 YILPRVY 741
            .:||.::
Human   486 RLLPGIF 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	ICMT	304..741	CDD:473892	120/525 (23%)
DHCR7	NP_001412036.1	ICMT	93..492	CDD:473892	106/464 (23%)