Protein Alignment LBR and Dhcr7

DIOPT Version :10

• Sequence 1: NP_726114.1
• Gene: LBR / 37482
• FlyBaseID: FBgn0034657
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: XP_006508539.2
• Gene: Dhcr7 / 13360
• MGIID: 1298378
• Length: 474
• Species: Mus musculus
• Alignment Length: 537
• Identity: 129/537 - (24%)
• Similarity: 200/537 - (37%)
• Gaps: 154/537 - (28%)

  Fly   292 ATPAEISCRQLKAPREFGG------------W--LGAFLFLLLL-PTAVYYLTWSCTARNACQFK 341
            |:.::.:..::|:|....|            |  |.:.:||||. |..|||...:|. :.:|...
Mouse     5 ASKSQHNAPKVKSPNGKAGSQGQWGRAWEVDWFSLASIIFLLLFAPFIVYYFIMACD-QYSCSLT 68

  Fly   342 HLNLGI------LLDVNYLTRQVF--QPRVVGAFAAYQVVVFLLV-----ALLPGRRVHLTRETY 393
            ...|.|      |.|:...|..|.  ..::...:.::||:::..:     ..|||         |
Mouse    69 APALDIATGHASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPG---------Y 124

  Fly   394 KFNCLAVSLTLLIASGVAEYLKYPV---VTFVLRHYLRFCIFGLVGAFVAAAWS----------- 444
            .......::|   .:||..  ||.|   ..:::.|.|.|     |.|::.:.:|
Mouse   125 VGGVQEGAIT---PAGVVN--KYEVNGLQAWLITHILWF-----VNAYLLSWFSPTIIFDNWIPL 179

  Fly   445 YWLVDTAKYNV---------LRQTLTNDYGRTGSFVVDFALGRQLNP---KWLGRVDWKQ-FQYR 496
            .|..:...|.|         |..|...|...||:|..::.:|.:.||   ||.   |:|. |..|
Mouse   180 LWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWF---DFKLFFNGR 241

  Fly   497 LSLVT-TLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAI 560
            ..:|. |||        .|.:..|.|  |..|::..:....|.:.            ..||||..
Mouse   242 PGIVAWTLI--------NLSFAAKQQ--ELYGHVTNSMILVNVLQ------------AIYVLDFF 284

  Fly   561 IFEHHLSSSFELQHEGYG-------CLLLLRYAATPYLLTAVTKYFYEQRVPISCWYAPLAVAAL 618
            ..|.....:.::.|:.:|       |:.|      |||.|....|.....|.:|   .|.|:..|
Mouse   285 WNETWYLKTIDICHDHFGWYLGWGDCVWL------PYLYTLQGLYLVYHPVQLS---TPNALGIL 340

  Fly   619 LSLGLLVKRFSCAYKYKYRL-NSQSPIFAN--------------IETIHT-----YQGSRLLLSG 663
            | |||:      .| |.:|: |.|..:|..              ||..:|     ...|:||:||
Mouse   341 L-LGLV------GY-YIFRMTNHQKDLFRRTDGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSG 397

  Fly   664 MWGWVRQPNYLGDIVALLALAAPMA----LRPAWPPVLGLSLIILLLLHRATRANARNQARYHSS 724
            .||..|..||.||::..||......    |     |...:..:.:||.||..|...|...:|...
Mouse   398 FWGVARHFNYTGDLMGSLAYCLACGGGHLL-----PYFYIIYMTILLTHRCLRDEHRCANKYGRD 457

  Fly   725 WQRYSTQVRSYILPRVY 741
            |:||:..|...:||.::
Mouse   458 WERYTAAVPYRLLPGIF 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	ICMT	304..741	CDD:473892	127/523 (24%)
Dhcr7	XP_006508539.2	ICMT	92..474	CDD:473892	107/447 (24%)